{"created":"2023-05-15T14:52:03.906304+00:00","id":71153,"links":{},"metadata":{"_buckets":{"deposit":"2c368d9e-8d56-4658-be62-4db1ebb0462d"},"_deposit":{"created_by":1,"id":"71153","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71153"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071153","sets":["10:28"]},"author_link":["699479","699495","699488","699493","699484","699489","699494","699487","699482","699490","699480","699491","699492","699485","699481","699483","699486"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-06-14","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"酸化ストレスは生活習慣病や老化を引き起こすことが知られ、酸化ストレスの一つである放射線においても、放射線がん治療が増加傾向にあることなどから注目が集まっている。正常組織を酸化ストレスから防護できる効果的な薬剤の開発は極めて重要な研究課題であるといえる。\n化学的に抗酸化能やフリーラジカル消去能が確認されている化合物は多数存在するが、生物学的にその機能が評価されているものは限られている。我々は、迅速で簡便な抗酸化剤のスクリーニング法を確立し（特願2012-72619）、昨年の本学会にて発表した。\n本法は、細胞障害因子によりラット胸腺細胞の細胞サイズが縮小する現象を利用しており、本法を用いることで、新しく設計合成した化合物に関して、生物効果の判定に要する期間とコストを大幅に削減することができる。我々は、酸化ストレスの一つである放射線を用いて、種々の抗酸化物質に関して、その放射線防護効果の検討を行ったので報告する。また、化学的なラジカル消去能との相関についても知見を得たので報告する。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第66回日本酸化ストレス学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関根, 絵美子"}],"nameIdentifiers":[{"nameIdentifier":"699479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西, 郁夫"}],"nameIdentifiers":[{"nameIdentifier":"699480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野, 恵美"}],"nameIdentifiers":[{"nameIdentifier":"699481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川, 卓志"}],"nameIdentifiers":[{"nameIdentifier":"699482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 謙一郎"}],"nameIdentifiers":[{"nameIdentifier":"699483","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井, 高志"}],"nameIdentifiers":[{"nameIdentifier":"699484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"699485","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 健"}],"nameIdentifiers":[{"nameIdentifier":"699486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"699487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 絵美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699490","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699494","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 健","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699495","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ラット胸腺細胞を用いた抗酸化剤のスクリーニング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット胸腺細胞を用いた抗酸化剤のスクリーニング"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-17"},"publish_date":"2013-06-17","publish_status":"0","recid":"71153","relation_version_is_last":true,"title":["ラット胸腺細胞を用いた抗酸化剤のスクリーニング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:54:34.924801+00:00"}