@misc{oai:repo.qst.go.jp:00071119,
 author = {Uzawa, Akiko and Hirayama, Ryoichi and Matsumoto, Yoshitaka and Koda, Kana and Koike, Sachiko and Ando, Koichi and Furusawa, Yoshiya and 鵜澤 玲子 and 平山 亮一 and 松本 孔貴 and 幸田 華奈 and 小池 幸子 and 古澤 佳也},
 month = {May},
 note = {In clinical use of heavy-ion beams, we cannot overlook skin response appearing in the acute period.  We previously experimented effects of fractionated irradiation on the mouse skin with carbon beams of 290 MeV/u.  Changing the number of fractions in therapy may alter the normal tissue damages; we have concluded that skin damage should be carefully studied when the number of fractions is changed in new clinical trials.
It is still unclear whether any specific LETs cause such change in skin reaction.  Here we irradiated mice feet with mono-energetic and SOBP carbon ions, to obtain dose response of early skin reaction at different LETs.
With an increase of LET, repair of skin damage may be decreased.  Required isoeffect total-dose increased linearly with the fraction numbers on a semi-logarithmic chart at low LET (20 and 40 keV/µm) SOBP beam.  Similar behaviors were also found at high LET (60 and 80 keV/µm) beam when the fraction numbers were large.  However, no increases of isoeffect dose were observed at few fractionations.  The same tendency was observed for monoenergetic carbon beams. Douglas-Fowler s Fe-plot could not fit to the results for few fractionations at high-LET region.  The a/b ratios obtained from the Fe-plot, the values were 71, 37, 11 and 2.9 for LETs at 20, 40, 60, and 80 keV/µm in the SOBP, respectively.
We conclude that irradiation with few fractionation number at high-LET produced much stronger effect on skin.  The LQ-model based Fe-plot could not fit skin reaction at few fractions at high-LET.  This result may account for clinical carbon therapy of lung tumors that requires larger doses than doses predicted by extrapolating from fractionation date., Heavy Ion in Therapy and Space Radiation Symposium 2013　（HITSRS2013)},
 title = {Fractionated Irradiation of Carbon Beam and the Isoeffect Dose on Acute Reaction of Skin},
 year = {2013}
}