{"created":"2023-05-15T14:52:01.525689+00:00","id":71117,"links":{},"metadata":{"_buckets":{"deposit":"3aa1d4b7-da4b-4819-9d36-eacaba011ead"},"_deposit":{"created_by":1,"id":"71117","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71117"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071117","sets":["10:28"]},"author_link":["699077","699066","699070","699083","699074","699082","699071","699064","699072","699088","699078","699085","699065","699069","699081","699086","699075","699076","699062","699084","699067","699089","699073","699063","699079","699068","699087","699080"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-23","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Regional alterations in extracellular dopamine levels can be observed in the striatum during performance of neuropsychological tasks using PET1. To increase detection of the alteration, dopamine reuptake inhibitor could be useful for producing a greater magnitude of change in 11C-raclopride binding2. Mazindol is a non-selective catecholamine reuptake inhibitor, which blocks dopamine reuptake and thus could be used as an enhancer of dopamine release by neuropsyhological tasks3. To investigate basic potency of mazindol in human, we measured occupancy of the dopamine transporter and change in 11C-raclopride binding using PET after single oral administration of mazindol.\nMethods:\nTwo sets of PET scans were acquired on six healthy volunteers after oral administration of placebo and 1.5 mg of mazindol. 11C-raclopride was injected at 3 hours after the administration of placebo or mazindol, and 18F-FE-PE2I was injected at 5 hours. In the brain, preset volumes of interest were applied on the spatially normalized PET images. Binding potential of sub-regions of striatum was calculated by the simplified reference tissue model using cerebellum as reference region. Dopamine transporter occupancy was calculated by the % change of the binding potential of 18F-FE-PE2I, and change in extracellular dopamine levels was measured by the % change of that of 11C-raclopride.\nResults:\nAfter oral administration of 1.5 mg of mazindol, the binding potential of 18F-FE-PE2I significantly reduced by 20 &#8211; 25 % (p < 0.01, paired t-test), indicating 20 &#8211; 25 % of dopamine transporters in the striatum was occupied by mazindol. Meanwhile, the binding potential of 11C-raclopride reduced by 4 &#8211; 6%, but the reduction was not significant, indicating the change in extracellular dopamine levels by mazindol without neuropsyhological tasks was small. The correlation between the occupancy of dopamine transporter and the change in 11C-raclopride binding was not significant, but there seemed a tendency that the occupancy was negatively related to the change in 11C-raclopride binding among subjects in the associative striatum.\nConclusions:\nAfter oral administration of 1.5 mg of mazindol, dopamine transporters were occupied in a small proportion, and the change in extracellular dopamine levels was minimal. Further studies with a larger sample size would be needed to investigate the relationship between the occupancy of dopamine transporter and the change in extracellular dopamine levels by oral administration of mazindol.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Brain'13 & BrainPET'13","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"699062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"699063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Jun"}],"nameIdentifiers":[{"nameIdentifier":"699064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Makiko"}],"nameIdentifiers":[{"nameIdentifier":"699065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujiwara, Hironobu"}],"nameIdentifiers":[{"nameIdentifier":"699066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eguchi, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"699067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie"}],"nameIdentifiers":[{"nameIdentifier":"699068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodaka, Fumitoshi"}],"nameIdentifiers":[{"nameIdentifier":"699069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahata, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"699070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Harumasa"}],"nameIdentifiers":[{"nameIdentifier":"699071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Youko"}],"nameIdentifiers":[{"nameIdentifier":"699072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamimoto, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"699073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"699074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"699075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 真希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 広臨","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699083","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑 圭輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南本 敬史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699088","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699089","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Occupancy of dopamine transporter and&#8232; the effect of dopamine reuptake inhibition&#8232; by mazindol in living human brain","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Occupancy of dopamine transporter and&#8232; the effect of dopamine reuptake inhibition&#8232; by mazindol in living human brain"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-28"},"publish_date":"2013-05-28","publish_status":"0","recid":"71117","relation_version_is_last":true,"title":["Occupancy of dopamine transporter and&#8232; the effect of dopamine reuptake inhibition&#8232; by mazindol in living human brain"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:55:00.254998+00:00"}