{"created":"2023-05-15T14:51:59.958567+00:00","id":71083,"links":{},"metadata":{"_buckets":{"deposit":"bade2a1d-55cd-4f73-8f99-f16c3656e425"},"_deposit":{"created_by":1,"id":"71083","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71083"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071083","sets":["10:28"]},"author_link":["698684","698680","698683","698682","698685","698686","698681","698687","698679","698688"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-04-26","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction The detection of early-stage tumors, especially in the metastatic case, is important for improving treatment efficacy and prolonging patient survival.\nSuper paramagnetic iron-oxide (SPIO) nanoparticles are a highly sensitive MRI contrast agent and have the potential to be a powerful tool for a wide range of clinical\nand pre-clinical cancer studies.1 However, after intravenous administration conventional SPIO nanoparticles (eg ferucarbotran) in the bloodstream are rapidly captured\nby the reticuloendothelial system (RES), predominantly in the liver. Therefore, to avoid recognition by the RES and effectively target tumour tissue, it is necessary to\nequip the SPIO nanoparticles with a \"stealth\" capability. Previously, it has been reported that polyion complex vesicles (Nano-PICsomes), which are composed of\nbiocompatible poly(ethylene glycol) (PEG) and poly(amino acid)s, can be easily engineered for size and are capable of prolonged circulation in the bloodstream.2, 3 In\nthis paper, a novel MR and fluorescence contrast nanocarrier (named \"SPIO-Cy5-PICsome\"), that is specific for targeted tumor imaging and is based on the\nencapsulation of FDA-approved SPIO nanoparticles inside Nano-PICsomes, was synthesized and evaluated in vitro and\nin vivo for its ability to detect small tumors with high-field MRI.\nMaterials and Methods The SPIO-Cy5-PICsomes were composed of ferucarbotran (Resovist®, Fujifilm RI Pharma)\nand two oppositely charged block copolymers: block-aniomer, fluorescence (Cy5)-labeled PEG-b-poly(α,β-aspartic\nacid) (Cy5-PEG-PAsp) and homo-catiomer, poly([5-aminopentyl]-α,β-aspartamide) (Homo-P(Asp-AP)) (Figure 1). A\nsolution of Cy5-PEG-PAsp and ferucarbotran was prepared and then mixed with the Homo-P(Asp-AP) solution in an\nequal unit ratio of charged polymers, and stirred with a vortex mixer. The SPIO-Cy5-PICsome solution was then added\nto the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) solution for cross-linking. The size of the\nSPIO-Cy5-PICsomes was controlled to be around 100 nm.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ISMRM 21th Annual Meeting and Exhibition","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kokuryo, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"698679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kano, Mitsunobu"}],"nameIdentifiers":[{"nameIdentifier":"698680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishiyama, Nobuhiro"}],"nameIdentifiers":[{"nameIdentifier":"698681","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"698682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"698683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"698684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"國領 大介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"狩野  光伸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698687","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698688","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"SPIO-loaded unilamellar polyion complex vesicles (SPIO-Cy5-PICsomes) as a high relaxivity contrast agent for tumor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SPIO-loaded unilamellar polyion complex vesicles (SPIO-Cy5-PICsomes) as a high relaxivity contrast agent for tumor"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-04-30"},"publish_date":"2013-04-30","publish_status":"0","recid":"71083","relation_version_is_last":true,"title":["SPIO-loaded unilamellar polyion complex vesicles (SPIO-Cy5-PICsomes) as a high relaxivity contrast agent for tumor"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:55:23.508338+00:00"}