{"created":"2023-05-15T14:51:57.915804+00:00","id":71036,"links":{},"metadata":{"_buckets":{"deposit":"426fc6ef-591e-40da-9cba-557947e8fa03"},"_deposit":{"created_by":1,"id":"71036","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71036"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071036","sets":["10:28"]},"author_link":["698193","698189","698199","698195","698200","698191","698201","698203","698192","698204","698194","698205","698190","698196","698198","698186","698187","698197","698202","698188"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-07-19","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【はじめに】原子力発電で利用されるウランは腎毒性物質として知られている。原発事故をはじめ、劣化ウラン弾汚染や原子力資源獲得競争による環境負荷の懸念などを背景に、ウランの毒性影響に関心がもたれ、放射線防護の観点から早急な対応が求められている。これまで我々は、標的臓器である腎臓のウランの挙動を調べ、ウランが近位直尿細管に選択的に蓄積し、組織損傷を引き起こしていることを示してきた。本研究では、微小ビームを用いたウラン局在量解析により、毒性発現および尿細管再生期における尿細管におけるウラン局在を調べた。\n【実験】動物の処置：Wistar系雄性ラット（10週齢）に酢酸ウラン（天然型）を背部皮下に一回投与（0.5 mg/kg）した。ウランの分析：腎臓中ウラン濃度は誘導結合プラズマ質量分析により測定した。腎臓内ウラン分布および局所量の解析は高エネルギー領域シンクロトロン放射光蛍光Ｘ線分析（SR-XRF）により調べた。下流部位近位尿細管の検出：SR-XRF測定試料の隣接切片について下流部位近位尿細管に特異的に存在するグルタミンシンターゼの免疫染色を行った。組織影響観察： TUNELおよびPAS染色した。\n【結果および考察】投与1日目ウランは下流部位近位尿細管に分布した。管腔側の刷子縁へのウラン沈着は認められず、尿細管上皮には腎臓平均ウラン濃度の50倍程度のウラン濃集部位が検出された。投与8日目では下流部位近位尿細管上皮の脱落が観察されたが、15日目になるとダメージ部位には再生尿細管が出現した。15日目の腎臓平均ウラン濃度は1日目の12％に減衰した。尿細管上皮のウラン濃集部位は減少したが、数ミクロン四方程度の微小領域に1日目と同等のウラン局所量の部位も検出された。このようなウラン濃集がばく露後どの程度持続するのか、今後明らかにする必要があると考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第39回日本毒性学会学術年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武田（本間）志乃"}],"nameIdentifiers":[{"nameIdentifier":"698186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小久保, 年章"}],"nameIdentifiers":[{"nameIdentifier":"698187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西, 輝昭"}],"nameIdentifiers":[{"nameIdentifier":"698188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"酢屋, 徳啓"}],"nameIdentifiers":[{"nameIdentifier":"698189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川, 将一"}],"nameIdentifiers":[{"nameIdentifier":"698190","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 享子"}],"nameIdentifiers":[{"nameIdentifier":"698191","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺田, 靖子"}],"nameIdentifiers":[{"nameIdentifier":"698192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早尾, 辰雄"}],"nameIdentifiers":[{"nameIdentifier":"698193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上, 達也"}],"nameIdentifiers":[{"nameIdentifier":"698194","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, まゆみ"}],"nameIdentifiers":[{"nameIdentifier":"698195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"698196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田 志乃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小久保 年章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698198","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698199","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"酢屋 徳啓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698200","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川 将一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698201","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早尾 辰雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698202","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698203","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698204","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"698205","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"腎尿細管のウラン濃集","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腎尿細管のウラン濃集"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-01-09"},"publish_date":"2013-01-09","publish_status":"0","recid":"71036","relation_version_is_last":true,"title":["腎尿細管のウラン濃集"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:55:56.343604+00:00"}