@misc{oai:repo.qst.go.jp:00071012,
 author = {Nakayama, Fumiaki and Umeda, Sachiko and Asada, Masahiro and Imamura, Toru and Imai, Takashi and 中山 文明 and 梅田 禎子 and 今井 高志},
 month = {Dec},
 note = {Several fibroblast growth factors (FGFs) have been found to be able to protect against radiation damage. In particular, the wide spectrum of FGF1 activity was expected to be advantageous to treat radiation injuries. However, FGF1 has poor thermal stability and a relatively short half-life <I>in vivo</I>; therefore, we created an FGF1:FGF2 chimera (FGFC) that showed greater structural stability than FGF1, resulting in more effective protection against radiation-induced intestinal injuries. Thus, this study evaluated the protective effects of FGFC against radiation-induced hair follicle damage in the absence of heparin. A portion of the dorsal skin from 7-week-old male BALB/c mice was depilated to induce the anagen phase of the hair growth cycle, and these mice received total body irradiation (TBI) with gamma-rays 6 days after depilation. Under these conditions, hair could grow after irradiation at 4Gy, but not at more than 6 Gy. Pre-treatment with FGFC enabled hair regeneration even after 6 Gy, although FGF1 did not regenerate it. The administration of FGFC without heparin reduced the induction of apoptosis in hair bulbs 24 h after irradiation and also decreased the appearance of activated-caspase-3 positive cells 8 h after irradiation, whereas FGF1 did not significantly decrease radiation-induced apoptosis. In contrast, K15 positive stem cells decreased in anagen hair follicles after irradiation. However, pre-treatment with FGFC maintained K15 positive stem cells in the bulge after irradiation.
 These findings suggest that FGFC exerts radioprotective activity on hair follicles and enhances hair regeneration through the protection of stem cells after radiation damage, and indicate that FGFC may be useful for the prevention and treatment of radiation-induced hair loss., The 37th Annual Meeting of the Japanese Society for Investigative Dermatology},
 title = {FGF chimeric growth factor (FGFC) promoted hair regeneration after radiation damage},
 year = {2012}
}