{"created":"2023-05-15T14:51:55.162406+00:00","id":70973,"links":{},"metadata":{"_buckets":{"deposit":"f803c195-5472-4867-890c-6b4aba7ce1a8"},"_deposit":{"created_by":1,"id":"70973","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70973"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070973","sets":["10:28"]},"author_link":["697553","697550","697546","697551","697549","697554","697548","697552","697547"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Potentially lethal damage (PLD) and its repair (PLDR) were studied in\nconfluent human fibroblasts by analyzing the kinetics of chromosome\nbreak rejoining in X-ray or heavy- ion irradiated cells that were\neither held in non-cycling G0 phase of the cell cycle or forced to\nproliferate immediately after irradiation. Fusion premature chromosome\ncondensation (PCC) was combined with fluorescence in situ\nhybridization (FISH) to study chromosomal aberrations in interphase.\nThe rejoining kinetics of PCC breaks was similar for each culture\ncondition after both X-ray and heavy-ion irradiation. However, after 6\nGy X-rays, the misrepair in cycling cells was 1.36, 2.8 times higher\nthan that in non-cycling cells. Twelve hours after exposure to 2 Gy of\n55keV/um silicon ions the misrepair in cycling cells was 0.56, only 2\ntimes higher than that in non-cycling cells. Whereas, after exposure\nto 2 Gy 200 keV/um or 440 keV/um iron ion beams misrepair was similar\nin non-cycling and cycling cells. . Since the majority of repair in\nG0/G1 occurs via the non-homologous end joining process (NHEJ),\nincreased PLDR in X-ray and silicon-ion irradiated cells may result\nfrom improved cell cycle specific rejoining fidelity through the NHEJ\npathway, which is not the case in high-LET iron-ion irradiated cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Radiation Research Society 58th Annual Meeting","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hua, Liu Cui"}],"nameIdentifiers":[{"nameIdentifier":"697546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawata, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"697547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigematsu, Naoyuki"}],"nameIdentifiers":[{"nameIdentifier":"697548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"George, Kerry"}],"nameIdentifiers":[{"nameIdentifier":"697549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A, Cucinotta Francesca"}],"nameIdentifiers":[{"nameIdentifier":"697550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"劉 翠華","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川田 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ジョージ ケリー","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"クシノッタ フランク","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697554","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Comparison on the repair of potentially lethal damage between exposure to low- and high-LET radiations from Kinetics and fidelity of chromosome rejoining in normal human fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison on the repair of potentially lethal damage between exposure to low- and high-LET radiations from Kinetics and fidelity of chromosome rejoining in normal human fibroblasts"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-09"},"publish_date":"2012-11-09","publish_status":"0","recid":"70973","relation_version_is_last":true,"title":["Comparison on the repair of potentially lethal damage between exposure to low- and high-LET radiations from Kinetics and fidelity of chromosome rejoining in normal human fibroblasts"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:56:40.238304+00:00"}