@misc{oai:repo.qst.go.jp:00070973,
 author = {Hua, Liu Cui and Kawata, Tetsuya and Shigematsu, Naoyuki and George, Kerry and A, Cucinotta Francesca and 劉 翠華 and 川田 哲也 and ジョージ ケリー and クシノッタ フランク},
 month = {Oct},
 note = {Potentially lethal damage (PLD) and its repair (PLDR) were studied in
confluent human fibroblasts by analyzing the kinetics of chromosome
break rejoining in X-ray or heavy- ion irradiated cells that were
either held in non-cycling G0 phase of the cell cycle or forced to
proliferate immediately after irradiation. Fusion premature chromosome
condensation (PCC) was combined with fluorescence in situ
hybridization (FISH) to study chromosomal aberrations in interphase.
The rejoining kinetics of PCC breaks was similar for each culture
condition after both X-ray and heavy-ion irradiation. However, after 6
Gy X-rays, the misrepair in cycling cells was 1.36, 2.8 times higher
than that in non-cycling cells. Twelve hours after exposure to 2 Gy of
55keV/um silicon ions the misrepair in cycling cells was 0.56, only 2
times higher than that in non-cycling cells. Whereas, after exposure
to 2 Gy 200 keV/um or 440 keV/um iron ion beams misrepair was similar
in non-cycling and cycling cells. . Since the majority of repair in
G0/G1 occurs via the non-homologous end joining process (NHEJ),
increased PLDR in X-ray and silicon-ion irradiated cells may result
from improved cell cycle specific rejoining fidelity through the NHEJ
pathway, which is not the case in high-LET iron-ion irradiated cells., Radiation Research Society 58th Annual Meeting},
 title = {Comparison on the repair of potentially lethal damage between exposure to low- and high-LET radiations from Kinetics and fidelity of chromosome rejoining in normal human fibroblasts},
 year = {2012}
}