{"created":"2023-05-15T14:51:54.192335+00:00","id":70952,"links":{},"metadata":{"_buckets":{"deposit":"206aefc6-514a-4e25-989f-76360fec2139"},"_deposit":{"created_by":1,"id":"70952","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70952"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070952","sets":["10:28"]},"author_link":["697255","697258","697268","697269","697262","697267","697261","697263","697266","697257","697256","697260","697270","697271","697264","697254","697265","697259"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】[11C]PIBの結合とアミロイドベータ (Ab)蓄積の関係を、異なるアミロイド病理を持つモデルマウスを用いて調べる。\n【方法】脳実質にAβ斑を形成するAPP23トランスジェニック(Tg)マウス、脳血管アミロイドアンギオパチー(CAA)を主な病理とするAPP-SL Tgマウス、野生型(WT) マウスに対して、[11C]PIBを投与後PET計測と連続採血を行い、[11C]PIBの脳内集積の定量値として全分布容積（VT）を求めた。さらに摘出脳の切片で[11C]PIBによるオートラジオグラフィー(ARG)を行い、A斑およびCAAへの[11C]PIBの結合の強さを、thioflavin-Sによる阻害の度合いによって評価を行った。Aβ蓄積は蛍光染色で評価した。\n【結果】Ab斑蓄積が顕著なAPP23 Tgマウスの大脳皮質および海馬ではVT値がWTマウスに比較して高かった。またAPP-SL Tgマウスの小脳にはCAA形成が見られ、脳幹に対するVTの比は小脳にCAA形成の無いAPP23 TgおよびWTマウスより若干高い値となった。ARGでは、APP-SL Tg マウス小脳のCAAやAPP23 Tgの大脳皮質及び海馬におけるAβ斑への[11C]PIBの結合が見られた。100 μMのthioflavin-Sの添加により CAAへの[11C]PIB結合はほぼ完全に阻害されたが、脳実質Ab斑への阻害は微弱であった。\n【結論】Tgマウスを用いたPETで、Ab蓄積が生体脳においてVTなどを指標に定量可能であることが裏付けられた。また、 [11C]PIBはCAAへ結合するものの、Aβ斑蓄積に比較すると結合が弱いことが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第31回日本認知症学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"697254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永, 正希"}],"nameIdentifiers":[{"nameIdentifier":"697255","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山, 将浩"}],"nameIdentifiers":[{"nameIdentifier":"697256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野, 麻衣子"}],"nameIdentifiers":[{"nameIdentifier":"697257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季, 斌"}],"nameIdentifiers":[{"nameIdentifier":"697258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田, 純"}],"nameIdentifiers":[{"nameIdentifier":"697259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"697260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"697261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"697262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永 正希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山 将浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 麻衣子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季 斌","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697271","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"アミロイド前駆体蛋白遺伝子導入マウスを用いたアミロイドbeta蓄積への[11C]PIB結合評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アミロイド前駆体蛋白遺伝子導入マウスを用いたアミロイドbeta蓄積への[11C]PIB結合評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-01"},"publish_date":"2012-11-01","publish_status":"0","recid":"70952","relation_version_is_last":true,"title":["アミロイド前駆体蛋白遺伝子導入マウスを用いたアミロイドbeta蓄積への[11C]PIB結合評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:56:55.054129+00:00"}