{"created":"2023-05-15T14:51:54.018240+00:00","id":70948,"links":{},"metadata":{"_buckets":{"deposit":"549c6e50-8665-4dd8-95a0-7d796c5e0c99"},"_deposit":{"created_by":1,"id":"70948","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70948"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070948","sets":["10:28"]},"author_link":["697207","697204","697200","697216","697209","697212","697219","697222","697211","697221","697210","697218","697220","697203","697201","697208","697217","697206","697214","697205","697202","697215","697223","697213"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景・目的】認知症における様々な神経精神症状は、患者のADLのみならず、患者および介護者のQOLの大きな阻害要因となる。Alzheimer病(AD)は高齢者において最も多い変性性認知症であり、脳内アミロイドβ蛋白(Aβ)の蓄積は最も特徴的な病理変化の一つであるが、Aβ蓄積と神経精神症状の関連については、未だ明らかになっていない。我々はPETを用いてAD患者のAβ蓄積を定量測定し、Aβ蓄積と様々な神経精神症状の関連について検討した。\n【対象・方法】対象はAD患者29例(73.9±7.9歳, 男性13/女性15, MMSE 19.9±5.1)。本研究の実施にあたっては、放射線医学総合研究所の倫理委員会より承認を得た。また全被験者に口頭と書面による説明を行い、本人ないしは家族から研究に参加する旨の同意書を書面で頂いた。[<sup>11</sup>C]PIBを約370MBq静脈投与し、Siemens社製ECAT EXACT HR+で90分間ダイナミックスキャンした。同日にPhillips社製の1.5T Interaを用いて3D T1強調MRI画像を撮像し、MRI画像を用いたPET画像の部分容積効果補正を行った。PMODを用いて小脳皮質を参照領域としたLogan plot解析を行い、結合能(BPND)を算出してAβ蓄積の指標とした。SPM5を用いてNeuropsychiatric Inventory(NPI)の下位項目のスコアとBPNDの相関解析を行った。\n【結果】NPIの各項目の中ではアパシーが最も頻度が高く(39.2％)、幻覚と多幸が最も稀な(7.1%)神経精神症状であった。NPIの下位項目の中ではアパシーのスコアが、両側上前頭回、両側眼窩前頭皮質、および左帯状回においてBPNDと有意な相関を認めた。他の神経精神症状とBPNDとの間には、有意な相関を認めなかった。\n【考察】前頭前野におけるAβ蓄積はAlzheimer病患者のアパシーに関連することが明らかになった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第31回日本認知症学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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俊章"}],"nameIdentifiers":[{"nameIdentifier":"697206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 真希子"}],"nameIdentifiers":[{"nameIdentifier":"697207","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"697208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"697209","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"桑原, 聡"}],"nameIdentifiers":[{"nameIdentifier":"697210","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"697211","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"697212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697213","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 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真希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697220","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697221","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697222","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697223","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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