{"created":"2023-05-15T14:51:53.673131+00:00","id":70940,"links":{},"metadata":{"_buckets":{"deposit":"aeb4d51a-f817-4cc9-8e80-c27bbd82a5ea"},"_deposit":{"created_by":1,"id":"70940","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70940"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070940","sets":["10:28"]},"author_link":["697105","697100","697106","697097","697094","697095","697099","697102","697096","697093","697103","697107","697108","697101","697104","697098"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】Translocator protein（18kDa）[TSPO]は正常肝臓での発現は低いが、肝臓の線維化に主要な働きをもつといわれる肝星細胞では活性化によりTSPOの発現がみられたとの報告がある。今回はTSPOのPET用リガンドとして弊所で開発した [18F]FEDACを用い四塩化炭素（CCｌ4）誘発による肝線維化モデルラットのPET撮像を実施し、病態との関連について検討した。【方法】SDラットに50%CCｌ4溶液を2回/週間、10週間まで反復腹腔内投与した。その間CCｌ4投与後3日目に[18F]FEDACのPET撮像を行った。また代謝物分析および免疫組織染色を実施した。【結果・考察】PETの結果、CCｌ4投与により[18F]FEDACの肝臓への取り込みが高くなり、また投与回数に伴いSUV25-30minが高くなる傾向を示した。Sirius red染色および抗TSPO抗体による免疫染色を行ない、線維化箇所におけるTSPOの発現および投与回数の増加による線維化の進行を確認した。代謝物分析により肝臓での未変化体存在比は投与回数と共に増加しておりTSPOとの結合の増加が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"697093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"697094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"697095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"697096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"697097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 勇一郎"}],"nameIdentifiers":[{"nameIdentifier":"697098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"697099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"697100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 勇一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697108","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"TSPOリガンド [18F]FEDACを用いたラット肝線維化のPETイメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TSPOリガンド [18F]FEDACを用いたラット肝線維化のPETイメージング"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-19"},"publish_date":"2012-10-19","publish_status":"0","recid":"70940","relation_version_is_last":true,"title":["TSPOリガンド [18F]FEDACを用いたラット肝線維化のPETイメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:57:04.368362+00:00"}