{"created":"2023-05-15T14:51:53.458270+00:00","id":70935,"links":{},"metadata":{"_buckets":{"deposit":"4739753f-4054-4ab0-a9e3-85052ed0ed04"},"_deposit":{"created_by":1,"id":"70935","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70935"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070935","sets":["10:28"]},"author_link":["697034","697032","697027","697033","697030","697031","697036","697025","697035","697026","697024","697029","697023","697028"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"代謝型グルタミン酸受容体1型(mGluR1)は小脳失調症やパーキンソン病などの病気に関与していると考えられているが、mGluR1の役割については解明されていない。これまでに、我々のグループでは新規PETプローブとして[18F]FITMの開発に成功している。今回、我々は、[18F]FITMの体内動態を改善するため、フッ素原子を塩素、臭素、ヨウ素原子に変換した 誘導体1-3、前駆体としてN-デスメチル体を合成した。[11C]CH3OTfを用いたメチル化反応では [11C]1-3が放射化学的収率で13.0±6.0％ (n=6)であった。 1-3の結合試験では、ハロゲン原子が大きくなるにつれ、活性が低下していくことが分かった。また、[11C]1-3において、ラット脳切片を用いたin vitro ARGでは、mGluR1が存在する小脳において高い結合能を示した。さらなる応用として、中半減期核種による標識についての検討も行った。詳細については本会にて発表する。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"697023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"697024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"697025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 勇一郎"}],"nameIdentifiers":[{"nameIdentifier":"697026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"697027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村, 利光"}],"nameIdentifiers":[{"nameIdentifier":"697028","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"697029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697031","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697032","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 勇一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697036","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"FITM誘導体を利用した代謝型グルタミン酸受容体1の新規イメージング剤の開発と動物評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"FITM誘導体を利用した代謝型グルタミン酸受容体1の新規イメージング剤の開発と動物評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-16"},"publish_date":"2012-10-16","publish_status":"0","recid":"70935","relation_version_is_last":true,"title":["FITM誘導体を利用した代謝型グルタミン酸受容体1の新規イメージング剤の開発と動物評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:57:07.748378+00:00"}