{"created":"2023-05-15T14:51:53.415558+00:00","id":70934,"links":{},"metadata":{"_buckets":{"deposit":"cc87f044-aa7b-4464-829e-2f77b16cd1df"},"_deposit":{"created_by":1,"id":"70934","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70934"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070934","sets":["10:28"]},"author_link":["697009","697016","697018","697022","697020","697011","697015","697014","697010","697017","697021","697012","697013","697019"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[18F]FITMは、代謝型グルタミン酸受容体1（mGluR1）のPETプローブとして開発され、これまでに動物の脳において高いmGluR1の特異結合が確認され、放医研で臨床研究の準備を進めている。今回[18F]FITMを用いてmGluR1の異常発現が報告されているメラノーマの腫瘍イメージングについて評価した。【方法】メラノーマB16F1またはB16F10腫瘍細胞を、C57BL/6JおよびBALB/C nu/nuマウスの皮下に移植してモデル動物を作製し、PET測定を実施した。【結果】PET 90-120minのヌードマウス皮下腫瘍の放射能集積は、B16F1がSUV2.8、B16F10はSUV2.4を示し、コントラストのよい画像を得ることができた。また、非標識FITM 3?/?を同時投与することにより[18F]FITMの集積は50%抑制された。この結果から[18F]FITMはメラノーマの新たなバイオマーカーになりえることが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"697009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"697010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"697011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"697012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"697013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"697014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 勇一郎"}],"nameIdentifiers":[{"nameIdentifier":"697015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 勇一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"697022","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"代謝型グルタミン酸受容体1 (mGluR1)PETリガンド[18F]FITMによる悪性黒色腫イメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"代謝型グルタミン酸受容体1 (mGluR1)PETリガンド[18F]FITMによる悪性黒色腫イメージング"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-16"},"publish_date":"2012-10-16","publish_status":"0","recid":"70934","relation_version_is_last":true,"title":["代謝型グルタミン酸受容体1 (mGluR1)PETリガンド[18F]FITMによる悪性黒色腫イメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:57:08.418570+00:00"}