@misc{oai:repo.qst.go.jp:00070910,
 author = {下川, 卓志 and 藤田, 英俊 and 清野, 研一郎 and 今井, 高志 and 下川 卓志 and 藤田 英俊 and 清野 研一郎 and 今井 高志},
 month = {Sep},
 note = {Metastasis control is one of the important issues in cancer treatment including radiation therapy (RT). Carbon-ion (C-ion)
RT is an advanced RT using positively-charged carbon ion particles, and has achieved better results, especially local
control, due to the biological properties and excellent dose distribution. Previously, we reported that lung metastasis was
notably repressed by the combined therapy of C-ion irradiation and dendritic cell (DC) immunotherapy in a mouse
metastasis model using a squamous cell carcinoma cell line, NRS1, inoculated in a leg of C3H/He mice.
In this study, we aimed to obtain evidences for expanding the range of application for the combined therapy. We
established mouse metastasis models using a lung cancer cell line, LLC, and an osteosarcoma cell line, LM8, inoculated
into C57BL/6J and C3H/He mice, respectively. Under conditions that there were no significant effects on growth of
transplanted tumor by the treatments, the number of lung metastasis was significantly decreased by only the combined
therapy, but not by C-ion irradiation or DC injection alone. This result clearly indicated that the combination therapy was
effective for repressing metastasis., 第71回日本癌学会学術総会},
 title = {炭素線-樹状細胞併用療法による肺転移抑制の適応拡大を目指した基礎研究},
 year = {2012}
}