@misc{oai:repo.qst.go.jp:00070863,
 author = {Kokuryo, Daisuke and Aoki, Ichio and Saga, Tsuneo and 國領 大介 and 青木 伊知男 and 佐賀 恒夫},
 month = {Sep},
 note = {Introduction: We have developed multi-functional liposomal nanoprobes containing a MR
contrast agent, a fluorescence dye and an anticancer drug. In a previous study, subcutaneous and
deep-seated tumor could be detected and visualized with the nanoprobes (Kokuryo D, et al: Proc. ISMRM
2010; etc). As the next step, we wish to apply the nanoprobes to lung tumors and other pulmonary disease.
However, it is difficult to detect signal in the lung using conventional MR imaging techniques because of low
proton density, short T2
*, strong susceptibility effects and respiratory motion. Recently, ultra-short echo-time
(UTE) imaging has been developed (Gewalt SL, et al: Magn Reson Med., 1993; etc) and utilized to evaluate
the signal changes in lung parenchyma for various animal models (Takahashi M: J Magn Reson Imaging,
2010; etc). As a preliminary step toward theragnostics using nanoprobe-based contrast agents such as
Gd-DTPA/DACHPt-loaded micelles (Kaida S: Cancer Res., 2010), in this study Gd-chelate contrast agents were evaluated for MRI of lung parenchyma and metastatic tumor., 2011 Worsl Molecular Imaging Congress (Wmic)},
 title = {Assessment of lung parenchyma and metastasis tumor using ultra-short echo-time (UTE) MRI with contrast agents},
 year = {2011}
}