{"created":"2023-05-15T14:51:50.181921+00:00","id":70860,"links":{},"metadata":{"_buckets":{"deposit":"3e5a70b9-99de-480b-a8b6-b234c658173d"},"_deposit":{"created_by":1,"id":"70860","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70860"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070860","sets":["10:28"]},"author_link":["696304","696296","696297","696303","696301","696306","696305","696300","696294","696302","696299","696298","696295"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-08-31","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It was reported that reactive oxygen species (ROS) were generated by heating an aqueous solution containing oxygen. The GSH dependent reduction of a nitroxyl radical, TEMPOL, is accelerated temperature dependently. This reaction can be restricted by adding SOD or by deoxygenating the reaction mixture, therefore used as an index of O2- generation. In this presentation, the hyperthermia-induced ROS scavenging ability of rat plasma was tested.\nA reaction mixture containing 0.1 mM nitroxyl radical (TEMPOL) and 1 mM GSH was prepared using 100 mM phosphate buffer (PB) containing 0.05 mM DTPA. The reaction mixture was kept in a screw-top vial, and was incubated in a water bath at 37 or 44[deg]C. The time course of the EPR signal of TEMPOL in the reaction mixture was measured by an X-band EPR spectrometer (JEOL, Tokyo, Japan). The similar experiment was done using rat plasma instead of 100 mM PB. Effect of BSA and/or ascorbic acid was tested.\nROS generation in an aqueous fluid containing oxygen at hyperthermal temperature was demonstrated. Adding 0.5% albumin to the reaction mixture could almost cancel the ROS generation at 37[deg]C; however, 0.5% albumin could not cancel the ROS at 44[deg]C, i.e. hyperthermal temperature. Ascorbic acid above 0.02 mM also could almost cancel ROS at 37[deg]C, however, 0.03 mM could cancel ROS at 44[deg]C.\nHyperthermia induced ROS in rat plasma can be mostly canceled by relatively high concentration of albumin and ascorbic acid in the plasma.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ICHO & JCTM 2012 (The 11th International Congress of Hyperthermic Oncology and The 29th Japanese Congress of Thermal Medicine)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ueno, Megumi"}],"nameIdentifiers":[{"nameIdentifier":"696294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nyuui, Minako"}],"nameIdentifiers":[{"nameIdentifier":"696295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"696296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anzai, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"696297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Toshihiko"}],"nameIdentifiers":[{"nameIdentifier":"696298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Kenichiro"}],"nameIdentifiers":[{"nameIdentifier":"696299","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uto, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"696300","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"696301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"乳井 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"696302","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"696303","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"696304","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤 俊彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"696305","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"696306","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Cancelation of Hyperhermia Induced Reactive Oxygen Species in Rat Plasma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cancelation of Hyperhermia Induced Reactive Oxygen Species in Rat Plasma"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-09-03"},"publish_date":"2012-09-03","publish_status":"0","recid":"70860","relation_version_is_last":true,"title":["Cancelation of Hyperhermia Induced Reactive Oxygen Species in Rat Plasma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:57:59.435093+00:00"}