@misc{oai:repo.qst.go.jp:00070853,
 author = {Kimura, Yasuyuki and Ito, Hiroshi and Yamada, Makiko and Kodaka, Fumitoshi and Takano, Harumasa and Fujiwara, Hironobu and Shimada, Hitoshi and Kanno, Iwao and Suhara, Tetsuya and 木村 泰之 and 伊藤 浩 and 山田 真希子 and 小高 文聰 and 高野 晴成 and 藤原 広臨 and 島田 斉 and 菅野 巖 and 須原 哲也},
 month = {Aug},
 note = {Positron emission tomography is a useful tool to investigate the effects of treatments in drug development and to diagnose diseases in their early stages without clinical symptoms. To perform multi-center studies or compare the findings with previously reported ones, inter-scanner differences in the quantification need to be considered. The causes of the differences could be more complicated in the dynamic imaging in the quantification of neuroreceptor in the brain than in the static imaging. We investigated inter-scanner differences between two clinical PET scanners, EXACT HR+ (Siemens / CTI, Knoxville, TN) and Eminence Sophia (Shimadzu Corp, Kyoto, Japan), in the quantification of dopamine D2 receptors using two radioligands with different affinity to dopamine D2 receptors, 11C-raclopride and 11C-FLB 457. Methods: Twelve healthy male volunteers were scanned twice after injections of 11C-raclopride and 11C-FLB 457 with HR+ or Eminence (6 males per scanner, age matched). 60 min-dynamic scan was performed after an injection of 222 MBq of 11C-raclopride, then 90 min-dynamic scan was performed after an injection of 222 MBq of 11C-FLB 457 with an interval of 60 min. Post-filter was adjusted to match the spatial resolution of reconstructed images. Binding potential of several regions was calculated by the simplified reference tissue model using cerebellum as a reference region. Results: The binding potential of striatal regions measured with 11C-raclopride showed no significant differences between the two scanners, while that of the cortical regions measured with 11C-FLB 457 showed significant differences (Eminence showed ~30% lower BPND than HR+). The time activity curves of 11C-FLB 457 measured with Eminence showed gradually higher concentration of radioactivity than those measured with HR+ in all regions. Conclusion: In the quantification of dopamine D2 receptor in the brain, inter-scanner differences varied between11C-raclopride and 11C-FLB 457., The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM12)},
 title = {Inter-scanner differences in dopamine
 receptor imaging},
 year = {2012}
}