@misc{oai:repo.qst.go.jp:00070841,
 author = {Shimada, Hitoshi and Shinoto, Hitoshi and Hirano, Shigeki and Mori, Takaaki and Eguchi, Yoko and Tanaka, Noriko and Kodaka, Fumitoshi and Fujiwara, Hironobu and Kimura, Yasuyuki and Kuwabara, Satoshi and Takano, Harumasa and Higuchi, Makoto and Ito, Hiroshi and Suhara, Tetsuya and 島田 斉 and 篠遠 仁 and 平野 成樹 and 森 崇明 and 江口 洋子 and 田中 典子 and 小高 文聰 and 藤原 広臨 and 木村 泰之 and 高野 晴成 and 樋口 真人 and 伊藤 浩 and 須原 哲也},
 month = {Jul},
 note = {Background and aims:[11C]AZD2184 has been recently developed as an amyloid imaging PET ligand that has high affinity for beta-amyloid (Aβ) and low nonspecific binding in the brain. We investigated the characteristics of [11C]AZD2184 retention in cognitive healthy elderlies and patients with cognitive impairments.
\nMethods:Participants were ten patients with Alzheimer's disease (AD), one patient with frontotemporal dementia (FTD), five patient with mild cognitive impairments (MCI) and age-matched nine healthy controls (HC). A dose (about 10 mCi) of [11C]AZD2184 was intravenously injected and sequential PET scans were performed for 90 min. Standardized uptake value ratio (SUVR) was calculated using cerebellar cortex as the reference region, and SUVR images were visually assessed in each subject. Voxel-wise distribution volume ratio (DVR) was also calculated using Logan plot analysis with the cerebellum as a reference region. Voxel-based group comparison was performed followed by VOI analysis.
\nResults:Visual assessment of SUVR images and quantitative analysis of DVR showed that Aβ deposition was high in parietal, lateral temporal and frontal cortices, especially in precuneus in the AD and MCI groups, and two of nine HC subjects. Seven of nine HC subjects and the FTD patient showed no evident Aβ deposition. Parametric group comparison showed that Aβ deposition was significantly greater in bilateral posterior cingulate gyri and precuneus in the AD group compared to the AZD-negative HC subjects (family-wise error corrected, p < 0.05). As for the MCI group, when parametric group comparison was performed using a more liberal statistical threshold (false discovery rate corrected, p < 0.01), Aβ deposition was significantly greater in the left middle occipital gyrus and bilateral precuneus than the AZD-negative HC subjects. Compared to [11C]PIB PET images in our previous study, non-specific ligand binding to white matter was low in [11C]AZD2184 PET. Furthermore, in patients with Aβ deposition, ligand binding to frontal cortex tended to be lower in [11C]AZD2184 PET than those in [11C]PIB PET.
\nConclusions:The present study demonstrated that [11C]AZD2184 PET is helpful to detect Aβ deposition in vivo. Patterns of distribution would be different between [11C]AZD2184 and [11C]PIB PET, suggesting that [11C]AZD2184 and [11C]PIB may detect different types of Aβ plaques., Alzheimer's Association International Conference (AAIC 2012)},
 title = {In vivo detection of amyloid deposition using [11C]AZD2184 PET},
 year = {2012}
}