{"created":"2023-05-15T14:51:49.060752+00:00","id":70835,"links":{},"metadata":{"_buckets":{"deposit":"f3d45922-8cf2-415c-af2e-98f9fda36026"},"_deposit":{"created_by":1,"id":"70835","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70835"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070835","sets":["10:28"]},"author_link":["695978","695980","695986","695985","695981","695979","695977","695984","695982","695983"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-07-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BRIP1 is a DNA helicase that directly interacts with the C-terminal BRCT repeat of the breast cancer susceptibility protein BRCA1 and plays an important role in BRCA1-dependent DNA repair and DNA damage-induced checkpoint control. Recent studies implicate BRIP1 as a moderate/low-penetrance breast cancer susceptibility gene. However, the phenotypic effects of BRIP1 dysfunction and its role in breast cancer tumorigenesis remain unclear. In this study, we used the three-dimensional culture of human mammary epithelial cells as a model of mammary gland morphogenesis, to explore the function of BRIP1 in acinar morphogenesis of mammary epithelial cells. BRIP1 knockdown in non-malignant MCF-10A mammary epithelial cells by RNA interference induced neoplastic-like changes such as abnormal cell adhesion, increased cell proliferation, large and irregular-shaped acini, invasive growth, and defective lumen formation. BRIP1-knockdown cells showed dysregulation of multiple signaling pathways and tumor-associated genes including SATB1, a key transcriptional regulator that promotes tumor growth and metastasis of breast cancer. These results suggest that BRIP1, by regulating multiple tumor-associated genes and signaling pathways, plays important roles not only in the development of mammary glands but also in the neoplastic conversion of mammary epithelial cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 22nd Biennial Congress of the European Association for Cancer Research","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Daino, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"695977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imaoka, Tatsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"695978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morioka, Takamitsu"}],"nameIdentifiers":[{"nameIdentifier":"695979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"695980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"695981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"臺野 和広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森岡 孝満","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695986","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-24"},"publish_date":"2012-07-24","publish_status":"0","recid":"70835","relation_version_is_last":true,"title":["Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:58:17.067637+00:00"}