{"created":"2023-05-15T14:51:47.038815+00:00","id":70789,"links":{},"metadata":{"_buckets":{"deposit":"0baa6fc2-408b-46d1-ac5a-98db9b4b8df0"},"_deposit":{"created_by":1,"id":"70789","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70789"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070789","sets":["10:28"]},"author_link":["695454","695451","695452","695457","695450","695458","695461","695453","695456","695455","695460","695459"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"統合失調症患者の死後脳研究においてD<SUB>1</sub>とD<SUB>2</sub>受容体のバラン\nスの変化が報告されている。従って、健常者脳において、D<SUB>1</sub>とD<SUB>2</\nsub>受容体濃度を測定し、その比の分布をデータベース化する事は、神経精神疾患の\n病態理解に役立つものと考える。本研究の目的は、同一個体においてPETを用いて線\n条体内外のD<SUB>1</sub>/D<SUB>2</sub>比の分布を評価する事である。＜方法＞9名\nの健常男性に<sup>11</sup>C-SCH23390、<sup>11</sup>C-raclopride、<sup>11</sup\nC-FLB457を用いた計3回のPETスキャンを施行した。各受容体結合能を算出し、線条\n体および線条体外についてD<SUB>1</sub>/D<SUB>2</sub>比の画像を作成した。＜結\n果＞線条体では、sensorimotor striatumのD<SUB>1</sub>/D<SUB>2</sub>比はassoci\native striatumやlimbic striatumに比べて有意に低かった。線条体外では、側頭葉\nのD<SUB>1</sub>/D<SUB>2</sub>比は他の皮質領域に比べて有意に低かった。＜考察\n＞線条体においてはD<SUB>2</sub>受容体が豊富なextrastrisomal matrixが感覚運動\n系に関連するという知見と一致した。線条体外では側頭葉でD<SUB>2</sub>受容体が\n多いという死後脳研究と一致した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第51回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"695450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"695451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原, 広臨"}],"nameIdentifiers":[{"nameIdentifier":"695452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"695453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"695454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"695455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 広臨","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"695461","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"線条体、線条体外におけるドーパミンD1、D2レセプターの分布比の健常者データベー ス","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"線条体、線条体外におけるドーパミンD1、D2レセプターの分布比の健常者データベー ス"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-06-07"},"publish_date":"2012-06-07","publish_status":"0","recid":"70789","relation_version_is_last":true,"title":["線条体、線条体外におけるドーパミンD1、D2レセプターの分布比の健常者データベー ス"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:58:48.764333+00:00"}