@misc{oai:repo.qst.go.jp:00070750,
 author = {Shinoto, Makoto and Yamada, Shigeru and Yoshikawa, Kyosan and Yasuda, Shigeo and Imada, Hiroshi and Kamada, Tadashi and 篠藤 誠 and 山田 滋 and 吉川 京燦 and 安田 茂雄 and 今田 浩史 and 鎌田 正},
 month = {May},
 note = {Purpose/Objective
The aim of this study was to evaluate the role of positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) in the indication of preoperative carbon ion radiotherapy for the patients with resectable pancreatic cancer.
Materials and Methods
The patients with resectable pancreatic cancer underwent preoperative short course carbon ion radiotherapy (CIRT) in our institution. On the PET-CT before CIRT, the tumor was contoured and the maximum standardized uptake value (SUVmax) was calculated. The SUVmax was compared between two groups, patients with and without distant recurrence after CIRT. The low-SUVmax and the high-SUVmax subgroups were created by categorizing patients above or below the median SUVmax. The impact of the SUVmax on the prognosis for patients was assessed by analyzing the correlations between the SUVmax and the distant metastasis free survival (DMFS) and overall survival (OS). In addition, the analysis was performed by following factors; age, carbohydrate antigen 19-9, tumor volume, and clinical stage.
Results
Twenty-one patients were included in this study. Sixteen of 21 patients underwent surgery. For the entire population, local recurrence was observed in no patient and distant metastasis in 13 patients (62%). The median SUVmax was 4.3 (range, 2.2-8.2). DMFS of the low-SUVmax group and the high- SUVmax group were 91% and 20% for 1 year and 71% and 0% for 3 year, respectively (p<0.0001). OS of the low-SUVmax group and the high-SUVmax group were 91% and50% for 1 year and 81% and 0% for 3 year, respectively (p<0.0001). An SUVmax >4.3 was the only risk factor for distant recurrence in the univariate analysis.
Conclusions
Our data indicated statistically significant correlation between SUVmax and DMFS. FDG-PET is considered to be useful to determine the indication of preoperative short course CIRT for the patients with resectable pancreatic cancer., ESTRO 31},
 title = {Role of FDG-PET as a predictor of distant failure in preoperative Carbon-ion radiotherapy for pancreatic cancer},
 year = {2012}
}