@misc{oai:repo.qst.go.jp:00070736,
 author = {Imai, Takashi and Ishikawa, Atsuko and Suga, Tomo and Shoji, Yoshimi and 今井 高志 and 石川 敦子 and 菅 智 and 荘司 好美},
 month = {May},
 note = {[Objectives] Cancer patients experience individual variation in normal tissue reactions after radiotherapy (RT). Such reactions to RT are quite complex, with multiple genetic factors contributing to a patient' s susceptibility for the reactions to RT. A risk of intestinal toxicity could be related to individual differences in radiosensitivities of the mitogenic crypt cells. We hypothesized that gene variation likely to affect cell-cycle regulation could contribute to heterogeneity in the risk of adverse intestinal reactions in CC patients undergoing RT.
[Methods] We examined 208 cervical cancer patients who have treated with pelvic radiotherapy as eligible for the genetic investigation. An early gastrointestinal reaction was graded using the NCICTC. The subjects were dichotomized into a lower-grade group (n = 150) and a higher-grade group (n = 58). Genomic DNA was genotyped, and association with the risk of adverse reaction for 49 functional SNPs of 22 candidate gens was assessed by single-locus, haplotype, and multilocus analysis.
[Results] Our analysis revealed two haplotypes of NPAT-ATM and AURKA and two single loci of PSMB8 and CASP7 contribute to the risk of adverse intestinal reaction after RT. Patients who had two or more of the risk genotype of these four genes showed higher risk than other patients.
[Conclusions] Genetic variations in the genes functioned on cell-cycle regulation may contribute to individual radiosensitivity of intestine. Identification of the novel risk genotypes would improve our understanding into the contribution of genetic factors to individual radiosensitivity and could be used to stratify the genetic risk in CC patients., The 2nd Japan-China Symposium on Cancer Research},
 title = {Influence of multiple genetic polymorphisms on early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy},
 year = {2012}
}