{"created":"2023-05-15T14:51:43.141974+00:00","id":70699,"links":{},"metadata":{"_buckets":{"deposit":"1fc5106d-7f88-4743-9e67-15ea341c0d2b"},"_deposit":{"created_by":1,"id":"70699","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70699"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070699","sets":["10:28"]},"author_link":["694439","694445","694449","694442","694441","694446","694448","694443","694447","694451","694438","694440","694450","694444"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】VSRAD plusはSPM2のco-registrationのプログラムを使っていた。VSRAD adv\nance（次期バージョン）ではSPM8に搭載されているDARTELを用いている。我々は、VS\nRAD plus(旧バージョン)とVSRAD advanceを同一症例のMRIに応用し、両者を比較検討\nした。【方法】対象は健常者14例(69±6歳)、軽度認知障害(MCI)11例(76±6歳)、晩\n期発症AD11例((78±4歳)、早期発症AD 6例(60±5歳)である。1.5テスラのMRI Intera\n を用いて矢状断像(TR: 9.33 msec、TE: 4.60 msec、slice thickness 1mm)を撮像し\nた。健常者、MCI, ADにおいてVSRAD plusとVSRAD advanceの関心領域のZスコアの比\n較を行った。MCI 8例, AD7例において約2年間の間隔をおいて2回MRIを撮像し、関心\n領域のZスコアの継時的変化を検討した。【結果】VSRAD plusとVSRAD advanceのZス\nコアの有意な相関（p ＜0.001、r^2^ =0.558）がみられた。早期発症ADで\nは、VSRAD advanceの解析で Zスコアが高くなる傾向がみられた。健常者14例と早期\nおよび晩期発症AD17例においてROC解析を行うと、VSRAD plusではAz 0.91、感度　89\n%、特異度79%であるのに対し、VSRAD advanceではAz 0.95感度97％、特異度87%であ\nった。MCI、ADにおいて約2年間の間隔でMRI検査を行った症例では、VSRAD plusでは\n関心領域のZスコアが15例中12例では増加し、3例では減少していたのに対し、VSRAD\nadvanceでは15例全例で経時的に関心領域のZスコアが増加していた。【結論】VSRAD\nadvanceを用いるとADの診断能が改善し、縦断的研究において萎縮の進行を正確に捉\nえることができると考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第30回日本認知症学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"694438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"694439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"694440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 崇明"}],"nameIdentifiers":[{"nameIdentifier":"694441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"694442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"694443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"694444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 崇明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694451","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"VSRAD次期バージョンの臨床評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"VSRAD次期バージョンの臨床評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-23"},"publish_date":"2012-02-23","publish_status":"0","recid":"70699","relation_version_is_last":true,"title":["VSRAD次期バージョンの臨床評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:59:54.452595+00:00"}