{"created":"2023-05-15T14:51:43.098422+00:00","id":70698,"links":{},"metadata":{"_buckets":{"deposit":"7d5bd57f-fb44-41c1-9697-b6d6f7c923c6"},"_deposit":{"created_by":1,"id":"70698","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70698"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070698","sets":["10:28"]},"author_link":["694427","694435","694436","694429","694419","694430","694437","694416","694422","694423","694417","694432","694434","694428","694424","694425","694418","694426","694420","694433","694431","694421"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】健常者においてアミロイド沈着が開始し、軽度認知障害(MCI)、アルツハイマー\n病(AD)、軽度認知障害(MCI)となる過程でどのようにアミロイド沈着が変化するのかは\n十分には明らかではない。本研究では、健常高齢者、MCI,ADにおけるアミロイド沈着\nの変化をPETで測定する。【対象・方法】対象は健常者11例（67±6歳、MMSE\n28±2）、MCI10例（76±5歳, MMSE 27±1、罹病期間1.8±0.8年）、AD8例（69±8歳\n、MMSE21±4、罹病期間2.4±1.4年）である。これらの症例で約2年間の間隔をおいて\n2回の[11C]PIBPETを行った。方法は[11C]PIBを約360MBq静脈投与し、PETスキャナー\nにて90分間撮像した。1回目および2回目のPET画像を2回目のMRIに位置合わせし、\nMRI上に小脳皮質、前頭皮質、前部および後部帯状回、頭頂皮質、外側側頭皮質に関心\n領域を設定し、小脳皮質を参照領域として非侵襲的Logan解析を行い、分布容積比\n(DVR)を求めた。【結果】3群間のDVRには差があり（p<0.001, repeated ANOVA),\nAD群は、健常群、MCI群に比べてDVRが高かった（p<0.001)。健常者、MCI, AD の3群\nにおいてDVRの2年間の増加に有意差はなかった(n.s.,ANOVA)。被験者全体(健常者、\nMCI, AD)において2年間でDVR が0.048単位 (1.8%/年）の増加がみられた（p< 0.02,\nPaired t-test）。【考察および結論】健常者、MCI,ADにおいて、脳内アミロイド沈着は\n増加していくことが確認された。　","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回日本神経学会学術大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"694416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"694417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"694418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三好, 美智恵"}],"nameIdentifiers":[{"nameIdentifier":"694419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 典子"}],"nameIdentifiers":[{"nameIdentifier":"694420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 康一"}],"nameIdentifiers":[{"nameIdentifier":"694421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"694422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 清"}],"nameIdentifiers":[{"nameIdentifier":"694423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"694424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"694425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"694426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三好 美智恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 康一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694433","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694435","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694436","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694437","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"アルツハイマー病、軽度認知障害、健常高齢者における[11C]PIBPETの2年間の変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アルツハイマー病、軽度認知障害、健常高齢者における[11C]PIBPETの2年間の変化"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-23"},"publish_date":"2012-02-23","publish_status":"0","recid":"70698","relation_version_is_last":true,"title":["アルツハイマー病、軽度認知障害、健常高齢者における[11C]PIBPETの2年間の変化"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:59:55.165968+00:00"}