{"created":"2023-05-15T14:51:43.054440+00:00","id":70697,"links":{},"metadata":{"_buckets":{"deposit":"5a5cf15d-e6d5-4ba8-9f4d-1836cf96e91b"},"_deposit":{"created_by":1,"id":"70697","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70697"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070697","sets":["10:28"]},"author_link":["694412","694402","694411","694398","694401","694396","694406","694415","694393","694408","694399","694400","694407","694405","694403","694395","694392","694409","694397","694413","694404","694394","694414","694410"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-09-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Obj ect iv e : The aim of our study was to investigate differential diagnostic performance of\nmeasurement of brain acetylcholinesterase (AChE) activity using PET in Dementia with Lewy\nbodies (DLB) and Alzheimer's disease (AD).\nMet hods: Participants were 14 patients with DLB [age:77+-6 yrs, MMSE16+-7], 25 patients\nwith AD [age75+-6 yrs, MMSE18+-4] and 18 age-matched healthy controls [age:72+-9 yrs,\nMMSE30+-1]. All subjects underwent PET scans with N-[11C]-methyl-4-piperidyl acetate\n(MP4A) to measure brain AChE activity. We did anatomical standardization of each brain image,\nand estimated voxel-based k3 values, an index of AChE activity, in a three-compartment model\nusing the metabolite corrected arterial input function. Volume of interest (VOIs) were identified\non k3 images in frontal lobe, temporal lobe, parietal lobe, occipital lobe, and anterior and\nposterior cingulate gyrus (PCG) using the Wake Forest University Pick Atlas. The differential\ndiagnostic performance was assessed by area under the receiver operating characteristic\n(ROC) curve analysis on k3 values in each VOIs between DLB and AD groups.\nResult s : Cortical AChE activities were lower in both the DLB group (% reduction compared with\nthe normal mean = -27.8%) and the AD group (-8.2%) than in the HC group (p < 0. 05). The\nlargest area under the ROC curves was observed in PCG (0.989, 95% CI, 0.926-0.999; sensitivity,\n0.950; specificity, 0.943).\nConclusions : More profound reduction of AChE activity was observed in DLB patients than AD\npatients as demonstrated in previous postmortem and PET studies. Patients with DLB are welldifferentiated\nfrom patients with AD by measurement of brain AChE activity using PET.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第34回日本神経科学大会（Neuro2011）","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"694392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"694393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinoto, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"694394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"694395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"694396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ota, Tsuneyoshi"}],"nameIdentifiers":[{"nameIdentifier":"694397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asahina, Masato"}],"nameIdentifiers":[{"nameIdentifier":"694398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aotsuka, Akiyo"}],"nameIdentifiers":[{"nameIdentifier":"694399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"694400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"694401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuwabara, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"694402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"694403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"694404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 康一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黄田 常嘉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青墳 章代","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694415","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-23"},"publish_date":"2012-02-23","publish_status":"0","recid":"70697","relation_version_is_last":true,"title":["Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:59:55.865276+00:00"}