@misc{oai:repo.qst.go.jp:00070697,
 author = {Shimada, Hitoshi and Hirano, Shigeki and Shinoto, Hitoshi and Sato, Koichi and Tanaka, Noriko and Ota, Tsuneyoshi and Asahina, Masato and Aotsuka, Akiyo and Ito, Hiroshi and Fukushi, Kiyoshi and Kuwabara, Satoshi and Irie, Toshiaki and Suhara, Tetsuya and 島田 斉 and 平野 成樹 and 篠遠 仁 and 佐藤 康一 and 田中 典子 and 黄田 常嘉 and 青墳 章代 and 伊藤 浩 and 福士 清 and 入江 俊章 and 須原 哲也},
 month = {Sep},
 note = {Obj ect iv e : The aim of our study was to investigate differential diagnostic performance of
measurement of brain acetylcholinesterase (AChE) activity using PET in Dementia with Lewy
bodies (DLB) and Alzheimer's disease (AD).
Met hods: Participants were 14 patients with DLB [age:77+-6 yrs, MMSE16+-7], 25 patients
with AD [age75+-6 yrs, MMSE18+-4] and 18 age-matched healthy controls [age:72+-9 yrs,
MMSE30+-1]. All subjects underwent PET scans with N-[11C]-methyl-4-piperidyl acetate
(MP4A) to measure brain AChE activity. We did anatomical standardization of each brain image,
and estimated voxel-based k3 values, an index of AChE activity, in a three-compartment model
using the metabolite corrected arterial input function. Volume of interest (VOIs) were identified
on k3 images in frontal lobe, temporal lobe, parietal lobe, occipital lobe, and anterior and
posterior cingulate gyrus (PCG) using the Wake Forest University Pick Atlas. The differential
diagnostic performance was assessed by area under the receiver operating characteristic
(ROC) curve analysis on k3 values in each VOIs between DLB and AD groups.
Result s : Cortical AChE activities were lower in both the DLB group (% reduction compared with
the normal mean = -27.8%) and the AD group (-8.2%) than in the HC group (p < 0. 05). The
largest area under the ROC curves was observed in PCG (0.989, 95% CI, 0.926-0.999; sensitivity,
0.950; specificity, 0.943).
Conclusions : More profound reduction of AChE activity was observed in DLB patients than AD
patients as demonstrated in previous postmortem and PET studies. Patients with DLB are welldifferentiated
from patients with AD by measurement of brain AChE activity using PET., 第34回日本神経科学大会（Neuro2011）},
 title = {Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement},
 year = {2011}
}