{"created":"2023-05-15T14:51:40.889368+00:00","id":70648,"links":{},"metadata":{"_buckets":{"deposit":"e8782967-010d-42f6-9de8-7c59736d4a10"},"_deposit":{"created_by":1,"id":"70648","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70648"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070648","sets":["10:28"]},"author_link":["693954","693960","693959","693966","693965","693953","693962","693957","693963","693951","693964","693955","693958","693956","693968","693967","693961","693952"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"18F-FDGは腫瘍へ高集積するが、治療に伴う炎症部位にも集積することから、治療効果判定には、腫瘍への集積の選択性が高い他のPETトレーサーの開発が望まれている。AIBは非天然アミノ酸のひとつであり、11C-AIBは腫瘍へ高集積することが報告されているが、炎症への集積の評価はされていない。本研究では、マウスモデルにおいてダイナミックPETを行い、腫瘍と炎症への集積を18F-FDGと比較した。方法:ヌードマウスの皮下に小細胞肺癌細胞を移植し、反対側の大腿筋にPETの24時間前にテレビン油を投与し炎症を誘発した。同じマウスで11C-AIB PET と18F-FDG PETを6時間の間隔で実施し、PET終了後に炎症が誘発されていることを病理標本で確認した。結果と考察:11C-AIBの腫瘍への集積は、時間とともに上昇し、18F-FDGより有意に高かった。それに対して、炎症への集積は18F-FDGより有意に低かった。11C-AIBは、治療効果判定に有用なPETトレーサーの候補であることが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第51回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"693951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 孝一"}],"nameIdentifiers":[{"nameIdentifier":"693952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭, 綾"}],"nameIdentifiers":[{"nameIdentifier":"693953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田, 真希"}],"nameIdentifiers":[{"nameIdentifier":"693954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤, 仁美"}],"nameIdentifiers":[{"nameIdentifier":"693955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 千里"}],"nameIdentifiers":[{"nameIdentifier":"693956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"693957","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"693958","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"693959","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693960","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 孝一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田 真希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤 仁美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 千里","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693968","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"マウスモデルにおける腫瘍と炎症部位への11C-AIBと18F-FDGの集積の比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウスモデルにおける腫瘍と炎症部位への11C-AIBと18F-FDGの集積の比較"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-11-28"},"publish_date":"2011-11-28","publish_status":"0","recid":"70648","relation_version_is_last":true,"title":["マウスモデルにおける腫瘍と炎症部位への11C-AIBと18F-FDGの集積の比較"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:00:29.776933+00:00"}