@misc{oai:repo.qst.go.jp:00070597,
 author = {Ohashi, Seiya and Yoshikawa, Kyosan and Toubaru, Sachiko and Hasebe, Mitsuhiko and Ishikawa, Hiroyuki and Sagou, Kenji and Tamura, Katsumi and Tanimoto, Katsuyuki and Kandatsu, Susumu and Mizoe, Junetsu and Fukumura, Toshimitsu and Saga, Tsuneo and Kawaguchi, Koji and Kamada, Tadashi and 大橋 靖也 and 吉川 京燦 and 桃原 幸子 and 長谷部 充彦 and 石川 博之 and 田村 克巳 and 谷本 克之 and 神立 進 and 溝江 純悦 and 福村 利光 and 佐賀 恒夫 and 鎌田 正},
 month = {Oct},
 note = {Phase I/II clinical trial on carbon ion radiotherapy (CIRT) has been conducted in patients with non-small cell lung cancer (NSCLC) in our institute, and we use C-11-methionine (MET) PET/CT for staging and monitoring treatment of NSCLC. Adrenal gland is one of common sites of metastasis from NSCLC. The objective of this study was to determine if MET-PET/CT could distinguish adrenal metastasis from benign gland.
Materials and Methods:
We performed a retrospective review of patients with NSCLC and found 125 cases evaluated with MET-PET/CT, Toshiba Aquiduo, who treated by CIRT and followed more than 2 years from 2006 to 2009. There were 71 adenocarcinoma, 48 squamous cell carcinoma and 6 other carcinoma. Five patients in these 125 patients proved developing adrenal metastasis, three in left adrenal gland and 2 in right adrenal gland. All these 5 adrenal lesions were histologically proved. We evaluated statistically, non-pared t-test, the difference between normal left and right adrenal gland MET uptake, and then we compared MET uptake in adrenal metastasis with normal adrenal gland. We analyzed the ability of MET-PET/CT for differential diagnosis by receiver operating characteristic (ROC) analysis.
Results:
Mean MET uptake of left and right normal adrenal gland was 3.9-2.0 and 2.8-1.0, respectively. There was significant difference in MET uptake of normal adrenal gland between left and right (p<0.01). Right adrenal gland showed higher MET uptake than left adrenal gland. It seemed because of spilling over into the right adrenal gland from adjacent liver with high accumulation of MET. Mean MET uptakes of left adrenal metastasis (3 tumors) and right (2 tumors) were 9.3 and 2.8, respectively. The ROC analysis of MET uptake of left adrenal metastasis and left normal adrenal gland resulted 0.77 area under the curve (AUC), that expressed as moderate accuracy. For right adrenal metastasis, AUC was 0.68 that was low accuracy.
Conclusions:
Normal adrenal gland showed significantly higher MET uptake in right than left adrenal gland. The diagnostic accuracy of MET-PET/CT for detecting adrenal metastasis from NSCLC was moderately accurate in left adrenal gland, but was low accurate in right adrenal gland., EANM'11 - Annual Congress of the European Association of Nuclear Medicine},
 title = {Clinical role of C-11-methionine-PET/CT in detection of adrenal metastasis from lung cancer.},
 year = {2011}
}