@misc{oai:repo.qst.go.jp:00070586,
 author = {Inubushi, Masayuki and Koizumi, Mitsuru and Saga, Tsuneo and 犬伏 正幸 and 小泉 満 and 佐賀 恒夫},
 month = {Oct},
 note = {Aim: The aim of the clinical study is to investigate whether PET imaging with a hypoxia tracer [18F]fluoroazomycin arabinoside (FAZA) can discriminate between radioresistant and radiosensitive cancers in histologically-proven primary lung cancer patients planned for radiotherapy. Here shown are the initial results on the [18F]FAZA uptake to the primary lesions.
Materials & Methods: Eighteen primary lung cancer patients were enrolled (63 +- 9 y/o, male: female = 11: 7, adenocarcinomas: squamous cell carcinomas: large cell carcinomas = 9: 5: 4, clinical stage IIIA: IIIB: IV = 7: 7: 4). [18F]FAZA-PET images were obtained 2 hours after the tracer injection (370 MBq). The standardized uptake values (SUV), the tumor-to-contralateral normal lung (T/N) ratio, the tumor-to-blood measured in the left ventricle (T/Bl) ratio, and the tumor-to-buck muscles (T/M) ratio were calculated as the semiquantitative parameters for [18F]FAZA uptakes to the primary lesions under the guidance of concomitant CT images. The SUV of [18F]Fluorodeoxylucose (FDG) was also compared with these parameters.
Results: There was no statistical difference in the maximum tumor diameter or in the SUV of [18F]FDG between genders, among histological types, or among clinical stages. The T/N ratio of [18F]FAZA was significantly higher in patients with large cell carcinomas than those with adenocarcinomas (5.0 +- 1.9 vs 2.5 +- 0.9, p < 0.0001). The T/Bl ratio of [18F]FAZA was significantly correlated with the maximum tumor diameter (R2 = 0.670, p < 0.0001) and with the SUV of [18F]FDG (R2 = 0.507, p < 0.0001), as well as with the SUV of [18F]FAZA (R2 = 0.748, p < 0.0001). The T/M ratio, however, seemed inappropriate as the parameter in lung cancer, since there was a gender difference in the SUV of [18F]FAZA to the buck muscles themselves (male 1.45 +- 0.12 vs female 1.26 +- 0.19, p = 0.02).
Conclusion: Histological difference was found in a parameter of [18F]FAZA uptake to the primary lesions in the lung cancer patients. In addition, reasonable relationships with the tumor size and with the tumor [18F]FDG uptake was found in another parameter of the [18F]FAZA uptake. The best parameter of the [18F]FAZA uptake for predicting the resistance to radiotherapy will be determined through following up the therapeutic outcome of these patients. (364 words), EANM'11 - Annual Congress of the European Association of Nuclear Medicine},
 title = {Initial Report on [18F]FAZA-PET/CT Clinical Study in Lung Cancer},
 year = {2011}
}