@misc{oai:repo.qst.go.jp:00070585,
 author = {Tanimoto, Katsuyuki and Yoshikawa, Kyosan and Shiraishi, Takahiro and Inagaki, Eri and Toubaru, Sachiko and Ohashi, Seiya and Obata, Takayuki and Saga, Tsuneo and Watanabe, Kazuhiro and Tsuji, Hiroshi and Ando, Yutaka and Kamada, Tadashi and Miyazaki, Masaru and et.al and 谷本 克之 and 吉川 京燦 and 白石 貴博 and 稲垣 枝里 and 桃原 幸子 and 大橋 靖也 and 小畠 隆行 and 佐賀 恒夫 and 渡邊 和洋 and 辻 比呂志 and 安藤 裕 and 鎌田 正 and 宮崎 勝},
 month = {Oct},
 note = {Objectives: FDG-PET provides quantitative information regarding the tumor glucose metabolism which is useful for the clinical diagnosis of tumor diseases. A diffusion weighted image (DWI) by MRI can be useful in detecting malignancies similar to FDG-PET imaging. We studied the potential prognostic significance of pre-surgery FDG-PET and MRI in pancreatic cancer.
Materials and Methods: Pre-surgery patients with either proven or suspected primary pancreatic cancer underwent a FDG-PET/CT and DWI by MRI. The malignancy or benignancy of excised specimens was pathologically confirmed in all cases. 
The apparent diffusion coefficient (ADC) was measured with DWI. We obtained standardized uptake value (SUV) in PET image. We can slightly improve SUV by using blood glucose corrected SUV (SUV*g: SUV X blood glucose level). The value of each factor for differential diagnosis of tumor malignancy was determined by receiver operating characteristic (ROC) analysis with suspected pancreatic cancer. Similarly, the predictive value of each factor for 1-year disease-free survival (DFS) and overall survival (OS) were determined by ROC analysis with proven pancreatic cancer. 
Results: On ROC analysis for differential diagnosis of tumor malignancy, the areas under the curve (AUC) of ADC, SUV and SUV*g were 0.830, 0.855 and 0.892, respectively. We considered that these three factors were good indexes for the diagnosis of tumor malignancy. For DFS, the AUC of ADC, SUV and SUV*g were 0.600, 0.843 and 0.811, respectively. The AUC of SUV and SUV*g were larger than the AUC of ADC. For OS, the AUC of ADC, SUV and SUV*g were 0.573, 0.648 and 0.867, respectively. The AUC of SUV*g was larger than the AUC of ADC and SUV. The SUV and SUV*g of FDG-PET/CT might be better indexes for estimation of prognosis. The 1-year DFS rate above the cutoff (SUV>4.3, SUV*g>400) were markedly lower than the rate below the cutoff (SUV>4.3, SUV*g>400) (0% vs. 67% p<0.002, 11% vs. 75% p<0.02). There is no statistically significant difference in the OS, but the OS rate above the cutoff (SUV*g>400) tended to be lower than the rate below the cutoff (SUV*g>400) (0% vs. 57%, p=0.06).
Conclusions: The results of FDG-PET/CT were significantly associated with outcome after definitive therapy of pancreatic cancer. FDG-PET/CT in preoperative evaluation of pancreatic tumor might be useful not only for differential diagnosis of tumor malignancy but also for estimation of prognosis., The 2011 EANM Congress},
 title = {PPre-surgery SUV and ADC as prognostic factor for outcome in pancreatic cancer},
 year = {2011}
}