{"created":"2023-05-15T14:51:37.313550+00:00","id":70566,"links":{},"metadata":{"_buckets":{"deposit":"fe901cdd-c9e9-4bf4-85b6-72d350e7b978"},"_deposit":{"created_by":1,"id":"70566","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70566"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070566","sets":["10:28"]},"author_link":["693032","693033","693031","693036","693037","693038","693029","693028","693034","693035","693030","693027"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose/Objective(s): Complete surgical resection is the only curative treatment for pancreatic cancer. Even if a curative resection is performed, the disease usually recurs, and the half of the failure pattern is local recurrence. We examined the effect of short course preoperative carbon-ion radiotherapy (CIRT) in terms of reducing the rate of local recurrence in patients undergoing resection for adenocarcinoma of the pancreas.\nMaterials/Methods: Patients with radiographically resectable pancreatic cancer were enrolled from October 2003 to July 2010. Eligibility included no CT involvement of celiac artery or SMA; adequate renal, hepatic and hematopoietic function; and ECOG PS 0-2. CIRT was given once daily, 4 days a week, for a fixed 8 fractions in 2 weeks. The dose was set to 30.0GyE and escalated to 36.8GyE at 5% increments with 5 levels. Treatment volumes included the location of the primary tumor and regional lymph nodes and retroperitoneal area. Surgery was performed 2-4 weeks after completion of CIRT.\nResults: Twenty-eight patients were enrolled on study. Twenty-five patients are eligible for this analysis. Five patients were treated at each of dose levels 1-2. Three patients were at dose level 3. Six patients were at each of dose levels 4-5. Twenty-one patients (84%) underwent resection. Reasons for no resections were: metastatic disease-3 and refusal-1 those were at dose levels 1-2. Although grade 3/4 toxicities were noted in 2 patients (liver abscess-1, PV thrombus-1), both of them were unrelated directly to CIRT. Median follow-up time is 13.9 months (range, 3.2-73.1). There has been no local failure in postoperative patients. Metastatic failure has occurred in 17 out of 25 patients (68%). Five-year survival rates in all patients and postoperative patients are 39% and 48%, respectively.\nConclusions: Short course preoperative CIRT seems to be a safe and effective modality in the management of resectable pancreatic cancer, providing satisfactory local control and offering a survival advantage without unacceptable morbidity.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ASTRO 53rd Annual Meeting","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shinoto, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"693027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"693028","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"693029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imada, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"693030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"693031","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"693032","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠藤 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今田 浩史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693038","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Efficacy and Safety of Short Course Carbon-ion Radiotherapy for Patients with Preoperative Pancreatic Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficacy and Safety of Short Course Carbon-ion Radiotherapy for Patients with Preoperative Pancreatic Cancer"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-11"},"publish_date":"2011-10-11","publish_status":"0","recid":"70566","relation_version_is_last":true,"title":["Efficacy and Safety of Short Course Carbon-ion Radiotherapy for Patients with Preoperative Pancreatic Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:01:26.282030+00:00"}