{"created":"2023-05-15T14:51:36.052621+00:00","id":70537,"links":{},"metadata":{"_buckets":{"deposit":"d27c987f-2012-4234-bcd0-957cdeabc727"},"_deposit":{"created_by":1,"id":"70537","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70537"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070537","sets":["10:28"]},"author_link":["692747","692755","692751","692759","692757","692754","692748","692760","692750","692749","692756","692758","692752","692753"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-09-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In Alzheimer's disease, hyperphosphorylated tau proteins assemble into fibri\nls, making up neurofibrillary tangles (NFTs), and are involved in neuronal l\noss. It is hypothesized that packaging of abnormal tau into NFTs protects ne\nurons against tau-induced neurodegeneration, while molecular mediators of NF\nT formation versus accumulation of neurotoxic, low-order tau assemblies rema\nin unidentified. p62 promotes autophagic degradation of ubiquitinated protei\nns, and sequesters them by forming an inclusion body. In mice transgenic for\nmutant human P301S tau protein, NFTs are abundantly developed in the spinal\ncord and brainstem but are accompanied by only modest neuronal loss in thes\ne areas. By contrast, massive neuron death without deposition of NFTs occurs\nin the hippocampus. Here, we investigated regional differences in levels of\np62 and their association with tau lesions between the brainstem and hippoc\nampus of P301S and wild-type mice to analyze roles of p62 in the tau pathoge\nnesis. Immunoreactivity for p62 was found in brainstem neurons of wild-type \nmice, and this immunolabeling was markedly intensified with accumulation of \nphosphorylated and ubiquitinated tau in P301S mice, indicating recruitment o\nf p62 to packaging of hyperphosphorylated and ubiquitinated tau. Meanwhile, \np62 was barely detectable in somas of hippocampal pyramidal neurons in both \nwild-type and P301S mice. In these hippocampal neurons, diffuse signals of p\nhosphorylated tau spatially overlapped with ubiquitin but not p62 immunoreac\ntivity. Moreover, autophagic activities in the hippocampus were higher than \nthat in the brainstem as assessed by immunoblotting for LC3. These findings \nsuggest that p62 and other components of autophagy are constitutively consum\ned at high levels in hippocampal neurons of P301S mice, leading to insuffici\nent reserve capacity for autophagic clearance of hyperphosphorylated tau and\nits segregation into inclusions and eventually neurotoxicity by misfolded b\nut unpackaged tau.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第34回日本神経科学大会（Neuro2011）","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ono, Maiko"}],"nameIdentifiers":[{"nameIdentifier":"692747","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ki, Hin"}],"nameIdentifiers":[{"nameIdentifier":"692748","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maruyama, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"692749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Jun"}],"nameIdentifiers":[{"nameIdentifier":"692750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamihisamatsu, Takeharu"}],"nameIdentifiers":[{"nameIdentifier":"692751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"692752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"692753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 麻衣子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季 斌","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山 将浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南久松 丈晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692760","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Selective autophagy in neurons and its involvement in the tau pathogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Selective autophagy in neurons and its involvement in the tau pathogenesis"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-09-17"},"publish_date":"2011-09-17","publish_status":"0","recid":"70537","relation_version_is_last":true,"title":["Selective autophagy in neurons and its involvement in the tau pathogenesis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:01:46.155602+00:00"}