@misc{oai:repo.qst.go.jp:00070508,
 author = {Hasegawa, Sumitaka and Morokoshi, Yukie and Furukawa, Takako and Saga, Tsuneo and 長谷川 純崇 and 諸越 幸恵 and 古川 高子 and 佐賀 恒夫},
 month = {Sep},
 note = {Here we show in vivo imaging of radiation-induced mouse thymic lymphoma (TL) by positron emission tomography (PET) and magnetic resonance imaging (MRI). Molecular imaging using PET and MRI are widely used not only for clinical cancer diagnostics but also for animal models of cancer. The aim of this study is to establish a method for monitoring mouse thymic lymphoma (TL) development induced by ionizing radiation. For radiation lymphomagenesis, we used fractionated whole body X-ray irradiation protocol and thus irradiated 4 weeks-old C57BL/6 mice at 1.2 Gy weekly for 4 consecutive weeks (total dose: 4.8 Gy). Three to six months after irradiation, affected mice showed body weight loss and difficulty in breathing. To assess the size of thymus of these affected mice, T1-weighted images were acquired by high magnetic field animal 7T-MRI scanner. PET with [18F]fluorodeoxyglucose (FDG) was also applied to mice with an enlarged thymus. FDG (~4MBq) was administrated into an affected mouse intravenously and a 10-min emission scan was started at 50 min after injection using Siemens Inveon small animal PET systems. FDG was highly accumulated in the affected thymus, suggesting that the lesions were metabolically active and malignant. Histopathological studies confirmed that they were T-cell lymphomas. Molecular imaging using PET and MRI allows us to trace the development and progression of mouse TL in living animals. Therefore, we propose that these techniques are powerful tools for detecting radiation-induced thymic lymphoma and would offer a new opportunity to understand the molecular and cellular mechanism(s) of radiation-induced mouse thymic lymphoma development., 14th International Congress of Radiation Research(ICRR’2011)},
 title = {Noninvasive monitoring of radiation-induced mouse thymic lymphoma by positron emission tomography and magnetic resonance imaging},
 year = {2011}
}