@misc{oai:repo.qst.go.jp:00070498,
 author = {Autsavapromporn, Narongchai and De, Toledo Sonia and Jay-Gerin, Jean-Paul and Harris, Andrew and Hua, Liu Cui and Uchihori, Yukio and K, Hei Tom and Azzam, Edouard and Suzuki, Masao and アッサワプロンポーン ナロンチャイ and 劉 翠華 and 内堀 幸夫 and 鈴木 雅雄},
 month = {Sep},
 note = {Understanding the mechanism (s) that underlie the bystander effects of low- or high-linear energy transfer (LET) radiations has been considered important for cancer therapy and a better understanding of the health risks associated with space exploration. We investigated the role of gap junction intercellular communication (GJIC) in propagation of events leading to amplification of stressful/bystander effects in confluent normal human fibroblasts (NB1RGB) cultures exposed to low doses/low fluences of low-or high-LET radiations using induction of DNA damage as endpoints.
Using microbeam irradiation, confluent NB1RBG cells were exposed to 5.35 keV X rays (LET 6 keV/um), 220 MeV carbon ions (LET 103 keV/um), 260 MeV neon ions (LET 380 keV/um), or 460 MeV argon ions (LET 1060 keV/um) under condition by which only 0.04% of cells in the population was targeted in the presence or absence of a gap junction inhibitor (AGA). Although the incidence of micronuclei formation induced by X-rays showed no difference irrespective of irradiation with or/ without gap junction inhibition, the frequency of micronuclei induced by carbon-ion microbeam was significantly higher in the absence of AGA than in its presence. Collectively, the results show that the propagation from irradiated to neighboring bystander cells, of clastogenic promoting effects depends on the LET and dose of the radiation, and that GJIC promotes the propagation of stressful bystander effects in high-LET-irradiated cell cultures. 
       In conclusion, the expression of the above low dose/low fluence radiation-induced stressful/bystander effects are consistent with our earlier observation of a similar propagation of toxic effect among cells in cultures wherein all cells were targeted by densely ionizing radiations.  Characterizing the nature of the propagated signaling molecules would have translational implications in radiotherapy and the formulation of countermeasures against toxic effects sustained by humans during space exploration., 14th International Congress of Radiation Research},
 title = {Targeted and non-targeted effects of low-or high-LET radiation},
 year = {2011}
}