{"created":"2023-05-15T14:51:33.114466+00:00","id":70470,"links":{},"metadata":{"_buckets":{"deposit":"3d63ebba-791f-4289-a057-f2f79c246a36"},"_deposit":{"created_by":1,"id":"70470","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70470"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070470","sets":["10:28"]},"author_link":["692042","692037","692043","692038","692044","692045","692040","692050","692047","692049","692046","692039","692036","692041","692048"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-07-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】我々は以前に、種々の食品成分(astaxanthin, canthaxanthin, zeaxanthin, lycopene, coenzyme Q10, sesamin, sesamol, catechin gallate, catechin hydrate, β-carotene, α-tocopherol)が、放射線照射によって誘導されるアポトーシスを顕著に抑制することをミトコンドリアROS消去アッセイにより明らかにした。特に、lycopeneの抑制能が最も高かった。本研究では、そのメカニズムを解明するために、これらの食品成分の活性酸素種・フリーラジカル消去活性を物理化学的手法を用いて評価した。\n【方法および結果】DMPOを用いたESRスピントラッピング法で食品成分のスーパーオキシド消去活性を比較すると、カテキン類が非常に優れた活性を示した。また、エタノール中、カテキン類やsesamolおよびα-tocopherolは、非常に効率良くDPPHラジカルを消去したのに対し、他の食品成分は消去活性を示さなかった。一方、これらの食品成分の還元能の指標であるイオン化エネルギー(IP)を密度汎関数法により計算すると、抗アポトーシス活性が高い食品成分ほどIP値が小さくなった。\n【結論】本研究で用いた食品成分の放射線誘導アポトーシスの抑制能は、活性酸素種・フリーラジカル消去活性とは相関せず、IP値が小さいほど抑制能が高いことが明らかとなった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第64回日本酸化ストレス学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中西, 郁夫"}],"nameIdentifiers":[{"nameIdentifier":"692036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"犬童, 寛子"}],"nameIdentifiers":[{"nameIdentifier":"692037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 敬"}],"nameIdentifiers":[{"nameIdentifier":"692038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田, 暢夫"}],"nameIdentifiers":[{"nameIdentifier":"692039","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"乳井, 美奈子"}],"nameIdentifiers":[{"nameIdentifier":"692040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 謙一郎"}],"nameIdentifiers":[{"nameIdentifier":"692041","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福原, 潔"}],"nameIdentifiers":[{"nameIdentifier":"692042","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福住, 俊一"}],"nameIdentifiers":[{"nameIdentifier":"692043","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"692044","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤, 俊彦"}],"nameIdentifiers":[{"nameIdentifier":"692045","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬嶋, 秀行"}],"nameIdentifiers":[{"nameIdentifier":"692046","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692047","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"乳井 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692048","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692049","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬嶋 秀行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692050","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"放射線誘導アポトーシスを抑制する食品成分の抗酸化活性評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線誘導アポトーシスを抑制する食品成分の抗酸化活性評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-04"},"publish_date":"2011-07-04","publish_status":"0","recid":"70470","relation_version_is_last":true,"title":["放射線誘導アポトーシスを抑制する食品成分の抗酸化活性評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:02:35.209924+00:00"}