{"created":"2023-05-15T14:51:32.717789+00:00","id":70461,"links":{},"metadata":{"_buckets":{"deposit":"99ac197b-f6c5-47fc-a561-61cef1465d75"},"_deposit":{"created_by":1,"id":"70461","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70461"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070461","sets":["10:28"]},"author_link":["691937","691940","691942","691950","691948","691949","691941","691939","691947","691951","691945","691938","691944","691943","691946"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-06-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The molecular design for novel phenolic antioxidants with high antioxidative and low pro-oxidant activities is of considerable importance with regard to the development of effective chemopreventive agents against oxidative stress and associated diseases.  However, very little is known about the detailed structure-activity relationship of phenolic antioxidants.  In this study, we examined the radical-scavenging rates of alpha-tocopherol and its analogues with various substituents on the 6-chromanol ring.\nalpha-Tocopherol efficiently scavenged galvinoxyl radical (GO) with the second-order rate constant (k) of 3.3 x 10(3) M(-1) s(-1) in deaerated acetonitrile at 298 K.  When the phytyl group at the C2 position in alpha-tocopherol was replaced by methyl group, no significant change in the k value was observed (3.2 x 10(3) M(-1) s(-1)).  On the other hand, a carboxyl group at the C2 position significantly retarded the GO-scavenging rate (k = 4.9 x 10(2) M(-1) s(-1)).  Among vitamin E analogues used in this study, 8-amino-2,2-dimethylchroman-6-ol showed the highest GO-scavenging activity (k = 1.4 x 10(4) M(-1) s(-1)).  The logarithm of the k values for alpha-tocopherol and its analogues were linearly correlated with the corresponding ionization potentials (IP) determined by the density functional theory calculations.  The smaller the IP value is, the stronger the radical-scavenging activity becomes.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"4th International Symposium on Nutrition, Oxygen Biology and Medicine","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"691937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inami, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"691938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Kei"}],"nameIdentifiers":[{"nameIdentifier":"691939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawashima, Tomonori"}],"nameIdentifiers":[{"nameIdentifier":"691940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Kenichiro"}],"nameIdentifiers":[{"nameIdentifier":"691941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuhara, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"691942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okuda, Haruhiro"}],"nameIdentifiers":[{"nameIdentifier":"691943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mochizuki, Masataka"}],"nameIdentifiers":[{"nameIdentifier":"691944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikota, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"691945","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuzumi, Shunichi"}],"nameIdentifiers":[{"nameIdentifier":"691946","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Toshihiko"}],"nameIdentifiers":[{"nameIdentifier":"691947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anzai, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"691948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川島 知憲","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691951","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Substituent Effect on the Radical-Scavenging Reactivity of Vitamin E Analogues","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Substituent Effect on the Radical-Scavenging Reactivity of Vitamin E Analogues"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-27"},"publish_date":"2011-06-27","publish_status":"0","recid":"70461","relation_version_is_last":true,"title":["Substituent Effect on the Radical-Scavenging Reactivity of Vitamin E Analogues"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:02:41.620295+00:00"}