{"created":"2023-05-15T14:51:29.963856+00:00","id":70398,"links":{},"metadata":{"_buckets":{"deposit":"55482c65-7edc-43f0-acb4-e56c1798009a"},"_deposit":{"created_by":1,"id":"70398","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70398"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070398","sets":["10:28"]},"author_link":["691250","691251","691253","691261","691262","691258","691252","691255","691254","691257","691260","691263","691256","691259"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-02-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/aims: To compare the efficacy and safety of the short-course carbon ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) in terms of tumor histological differentiation.  Methods: The study consisted of 63 patients undergoing C-ion RT of 52.8 GyE in 4 fractions between April 2000 and March 2003. Eligibility criteria were as follows: biopsy-proven HCC; recurrent or residual tumor after other ineffective treatments or no indication for any other treatment; no tumor thrombosis of main trunk of portal vein; no other viable lesion outside the planning target volume; no prior radiotherapy for target tumors; hepatic disorder of Child-Pugh classification A or B; ECOG performance status of 0-2; no other active cancer; and digestive tract not in contact with clinical target volume. Maximum tumor diameter was 4.0cm (range 1.2-12.0 cm). Four were well differentiated tumor, 2 were well to moderately-differentiated, 51 were moderately differentiated, 4 were moderately to poorly-differentiated, and 2 were poorly differentiated. The total dose delivered was 52.8 GyE in 4 fractions for 1 week. The dose per fraction was 13.2 GyE. Results: The 5-year local control rates were 100.0% in the well differentiated group, 96.0% in the moderately differentiated group, 83.3% in the poorly differentiated group, respectively. The 5-year overall survival and cause-specific survival rates were 33.3% and 33.3% in the well differentiated group, 23.4% and 32.8% in the moderately differentiated group, and 25.0% and 25.0% in the poorly differentiated group, respectively. There were no significant differences (P = 0.710, P = 0.977, respectively). Further, there were no significant differences in late liver toxicity, and no hepatic failure resulting from the therapy and no treatment-related death occurred. Conclusions: Excellent local control was obtained independent of tumor histological differentiation. Short-course C-ion RT appears to be an effective and safe treatment modality for all histological type of HCC. Outcomes after short-course carbon ion radiotherapy for patients with hepatocellular carcinoma according to tumor size.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 21st Conference of the Asian Pacific Association for the Study of the Liver","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imada, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"691250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"691251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oonishi, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"691252","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"691253","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinoto, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"691254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"691255","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokosuka, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"691256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今田 浩史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西 和彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠藤 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横須賀 収","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"691263","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Comparison of efficacy and safety of short-course carbon ion radiotherapy for patients with hepatocellular carcinoma depending on the histological differentiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of efficacy and safety of short-course carbon ion radiotherapy for patients with hepatocellular carcinoma depending on the histological differentiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-02-22"},"publish_date":"2011-02-22","publish_status":"0","recid":"70398","relation_version_is_last":true,"title":["Comparison of efficacy and safety of short-course carbon ion radiotherapy for patients with hepatocellular carcinoma depending on the histological differentiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:03:24.495060+00:00"}