@misc{oai:repo.qst.go.jp:00070283,
 author = {Toubaru, Sachiko and Yoshikawa, Kyosan and Ohashi, Seiya and Hasebe, Mitsuhiko and Ishikawa, Hiroyuki and Sagou, Kenji and Tamura, Katsumi and Tanimoto, Katsuyuki and Kandatsu, Susumu and Mizoe, Junetsu and Fukumura, Toshimitsu and Saga, Tsuneo and Kawaguchi, Koji and Kamada, Tadashi and 桃原 幸子 and 吉川 京燦 and 大橋 靖也 and 長谷部 充彦 and 石川 博之 and 田村 克巳 and 谷本 克之 and 神立 進 and 溝江 純悦 and 福村 利光 and 佐賀 恒夫 and 鎌田 正},
 month = {Oct},
 note = {[PURPOSE] Manyhead and neck cancers show relatively high accumulation of C-11 methionine(MET) by PET, but normal parotid gland also accumulates MET at some level.Therefore it sometimes is very important to distinguish cancer accumulationfrom physiological accumulation in parotid gland. In this study, primaryparotid cancers localized in parotid gland were evaluated by MET-PET or PET/CTfor detectability and diagnostic ability. [MATERIALS AND METHODS] We reviewedMET-PET and PET/CT images of primary parotid cancer from May 1995 to May 2009,and picked 44 patients up with cancer localized in parotid gland. There were 32pretherapeutic and 12 postoperative recurrent cases. Fifteen cases were adenoidcystic carcinomas, 12 cases were adenocarcinoma, 4 cases were mucoepidermoidcarcinoma and 13 cases were others. All cases were confirmed by pathology. Theaccumulation of tumor was compared to contralateral normal parotid gland usingTNR (tumor to normal tissue ratio). There were 40 cases that we could confirmthe existence of normal parotid grand tissue around the tumor by MRI, weevaluated the ability of MET-PET and PET/CT for visually detecting the tumorboundary in surrounding normal parotid tissue. [RESULTS] Average TNR of METaccumulation was 7.3 (1.5-28.1) in parotid gland cancer, and 4.3 (1.1-10.0) incontralateral normal parotid gland. The average TNR of parotid gland cancer wassignificantly greater than that of contralateral normal parotid gland([[Unsupported Character - 検]][[Unsupported Character -定]][[Unsupported Character - 法]], p=0.0001). The boundaryof tumor surrounded by normal parotid tissue was visually detected in 28 casesout of 40 cases (70%). The tumor activity of MET was higher than surroundingnormal tissue activity in 26 cases, and was lower in 2 cases. Tumor was totallyincluded within normal parotid tissue in 4 cases, and was protruded from normalparotid tissue in 22 cases. Assuming that the contralateral parotid glands weretrue negative tissue, we calculated the diagnostic capability of MET forparotid grand tumor. Sensitivity, specificity and accuracy for malignancy ofparotid grand tumor using 4.9 as cutoff value were 65.9%, 70.5% and 68.2%,respectively. [Conclusion] The average MET accumulation of parotid gland cancerwas significantly greater than that of contralateral normal parotid gland.Parotid grand cancer was able to distinguish visually from surrounding normalparotid tissue in 70% of the cases., The 2010 EANM Congress},
 title = {Diagnostic capability of C-11 methionine PET for parotid gland cancer},
 year = {2010}
}