{"created":"2023-05-15T14:51:19.194432+00:00","id":70157,"links":{},"metadata":{"_buckets":{"deposit":"e940dc13-ac24-4c49-8afb-8759d5a9a134"},"_deposit":{"created_by":1,"id":"70157","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70157"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070157","sets":["10:28"]},"author_link":["688889","688891","688892","688884","688888","688885","688890","688881","688883","688882","688887","688886"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-04-11","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】アルツハイマー型認知症(AD)は脳内コリン系障害を来たし、認知機能障害を起こす疾患であり、脳内アセチルコリンエステラーゼ(ACｈE)を阻害することが有効な治療法として確立し、現在治療薬として用いられている。今回前頭側頭型認知症(FTD)患者に対してPETを用いて脳内AChEを定量測定し、ADとの相違について検討した。【方法】[<SUP>11</SUP>C] MP4AとPETを用いて動脈血採血のもと大脳を撮影し、2コンパートメント3パラメータモデルと非線形最小二乗法を用いて脳内AChE活性の指標となるk<SUB>3</SUB>値を算出した。対象はFTD8例（年齢60±7、MMSE 14±9）、若年AD24例(年齢60±6、MMSE17 ±4)、健常者17例(年齢58±9、MMSE29 ±1)である。【結果】健常者と比べ若年ADでは広範かつ高度の大脳皮質AChEを認めたが、FTDでは健常者と有意差を認めなかった。【結語】ADとは異なり、FTDではコリン系神経障害は軽微であり脳内AChE阻害薬の効果は期待できない。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第107回日本内科学会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"688881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"688882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"688883","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"688884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"688885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"688886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"688887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"688888","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"688889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"688890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"688891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"688892","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PETを用いたアルツハイマー型認知症と前頭側頭型認知症の脳内アセチルコリンエステラーゼ活性定量測定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PETを用いたアルツハイマー型認知症と前頭側頭型認知症の脳内アセチルコリンエステラーゼ活性定量測定"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-06-16"},"publish_date":"2010-06-16","publish_status":"0","recid":"70157","relation_version_is_last":true,"title":["PETを用いたアルツハイマー型認知症と前頭側頭型認知症の脳内アセチルコリンエステラーゼ活性定量測定"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:06:11.962020+00:00"}