@misc{oai:repo.qst.go.jp:00070129,
 author = {Jingu, Keiichi and Mizoe, Junetsu and Hasegawa, Azusa and Bessho, Hiroki and Morikawa, Takamichi and Tsuji, Hiroshi and Kamada, Tadashi and Tsujii, Hirohiko and 神宮 啓一 and 溝江 純悦 and 長谷川 安都佐 and 別所 央城 and 森川 貴迪 and 辻 比呂志 and 鎌田 正 and 辻井 博彦},
 month = {May},
 note = {[Purpose]
To evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) with 70.4 GyE for unresectable bone and soft tissue sarcoma of the adult head and neck.
[Materials and Methods]
Thirty-three patients (mean age, 46.2 years) with bone and soft tissue sarcoma of the head and neck who treated by C-ion RT with 70.4 GyE/16 fractions (fr.) were enrolled into this study. The endpoints were acute and late reactions of normal tissues, the local control rate and the overall survival rate. Additionally, the efficacy of the treatment with high-dose was compared with our historical results using C-ion RT with 57.6 or 64.0 GyE/16 fr.
[Results]
The median follow-up period was 32.4 months. The 3-year local control rate and overall survival rate were 85.6% (95% confidence interval (CI) = 69.4-100%) and 75.2% (95% CI= 49.2-100%), respectively. In comparison with our historical results (n=14), the local control rate with 70.4 GyE was significantly better than thatwith 57.6 or 64.0 GyE (3-year, 85.6% vs. 21.4%, p<0.0001), and the dose escalation of C-ion RT tended to improve also the overall survival (3-year, 75.2% vs. 42.9%, p=0.06).
A grade 3 acute reaction was observed in only 1 patient. With regard to late reactions, visual loss was observed in 1 patient, and Grade 3 toxicity of the maxillary bone was observed in 4 patients.
[Conclusion]
C-ion RT with 70.4 GyE/16fr. for bone and soft tissue sarcoma of the adult head and neck appears to be effective and has acceptable toxicity. Moreover, the results using 70.4 GyE/16fr. were significantly better than our historical results using 57.6 or 64.0 GyE/16 fr., 第49回粒子線治療世界会議},
 title = {Carbon ion radiation therapy for unresectable adult bone and soft tissue sarcoma of the head and neck},
 year = {2010}
}