{"created":"2023-05-15T14:51:16.015490+00:00","id":70084,"links":{},"metadata":{"_buckets":{"deposit":"b0ab8b30-1027-4296-a92b-2a3d2cd2b62f"},"_deposit":{"created_by":1,"id":"70084","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70084"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070084","sets":["10:28"]},"author_link":["688223","688228","688226","688227","688229","688225","688230","688224"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-04-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this work, we investigate the possible role of BRCA1 in telomerase\nregulation in response to ionizing radiation (IR). The two human breast\ncancer cell lines expressing either BRCA-null (HCC1937) or BRCA1-wild type\n(MCF-7) cell lines were exposed to 4Gy of carbon ions. At different time\npoint following radiation, cell cycle distribution was detected by flow\ncytometric analysis; telomerase activity was determined by PCR ELISA; the\nexpression of hTERT mRNA, a catalytic subunit of telomerase complex, was\ndetermined by RT-PCR; the expression of telomerase protein, BRCA1 and p21\nwas examined by Western blotting. The results showed that a strong\ndown-regulation of telomerase activity, telomerase expression and hTERT mRNA\nwas observed in MCF-7 cells following irradiation. At the same time, IR\ninduced a significant G2 arrest in these cells. In contrast, neither\ndown-regulation of telomerase activity nor G2 block was detected in HCC1937.\nFurthermore, the decline in telomerase expression was rescued when G2\ncheckpoint was abrogated in MCF-7. The data suggest that inhibition of\ntelomerase is largely BRCA1-dependent, which is mediated by G2 checkpoint.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"平成21年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Hong"}],"nameIdentifiers":[{"nameIdentifier":"688223","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Yanling"}],"nameIdentifiers":[{"nameIdentifier":"688224","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"688225","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"688226","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Ning"}],"nameIdentifiers":[{"nameIdentifier":"688227","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhou, Xin"}],"nameIdentifiers":[{"nameIdentifier":"688228","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"688229","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"688230","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-04-21"},"publish_date":"2010-04-21","publish_status":"0","recid":"70084","relation_version_is_last":true,"title":["Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:07:00.828834+00:00"}