{"created":"2023-05-15T14:51:13.936069+00:00","id":70036,"links":{},"metadata":{"_buckets":{"deposit":"07b4fece-7fb9-4ccf-8f79-7a122b1c721e"},"_deposit":{"created_by":1,"id":"70036","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70036"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070036","sets":["10:28"]},"author_link":["687681","687668","687669","687677","687671","687678","687676","687683","687680","687672","687670","687674","687675","687673","687684","687682","687679"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study is to clarify cell cycle distribution and cytotoxicity after carbon-ion beams (C-ions). One human malignant melanoma cell line, HMV-I was exposed to X-rays or 290 MeV/u C-ions at the center of SOBP. We applied flow cytometry technique and colony formation assay. C-ions induced G2/M arrest effectively more than X-rays at 24 h. The iso-effect dose, i.e. the 10% survival dose (5.0Gy for X-rays, 2.7Gy for C-ions) was used to examine the cell cycle kinetics. G2/M fraction increased immediately after irradiations, and showed a peak at 15 h. G2/M arrest cells were stayed long time after C-ions, whereas it released quickly after X-rays. In addition, the mRNA expression of molecules related with the arrest was suppressed with D10 dose and the effects were transitory after X-rays, whereas C-ions showed prolonged suppression. The arrest was released significantly by caffeine, and the cell killing by C-ions was enhanced with caffeine together. It is suggested that the release from G2/M arrest after C-ions can enhance the cytotoxic effects. Repair of complex DNA damage by C-ions takes long time. When it released intermediate of the process, incomplete repaired damage cause cell death.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"MICROS 2009 15th International Symposium on Microdosimetry","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Yoshitaka"}],"nameIdentifiers":[{"nameIdentifier":"687668","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirayama, Ryoichi"}],"nameIdentifiers":[{"nameIdentifier":"687669","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sai, Sei"}],"nameIdentifiers":[{"nameIdentifier":"687670","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"687671","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uzawa, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"687672","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takase, Nobuhiro"}],"nameIdentifiers":[{"nameIdentifier":"687673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koike, Sachiko"}],"nameIdentifiers":[{"nameIdentifier":"687674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"687675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"687676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687677","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔 星","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高瀬 信宏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687681","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687684","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ABROGATION OF THE G2/M ARREST ENHANCED THE CYTOTOXIC EFFECTS BY CARBON-ION BEAMS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ABROGATION OF THE G2/M ARREST ENHANCED THE CYTOTOXIC EFFECTS BY CARBON-ION BEAMS"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-02-19"},"publish_date":"2010-02-19","publish_status":"0","recid":"70036","relation_version_is_last":true,"title":["ABROGATION OF THE G2/M ARREST ENHANCED THE CYTOTOXIC EFFECTS BY CARBON-ION BEAMS"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:07:34.684716+00:00"}