{"created":"2023-05-15T14:51:11.758698+00:00","id":69986,"links":{},"metadata":{"_buckets":{"deposit":"3a0fbceb-e3d7-4909-b989-e56510828b33"},"_deposit":{"created_by":1,"id":"69986","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69986"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069986","sets":["10:28"]},"author_link":["687184","687189","687190","687180","687182","687186","687183","687188","687185","687181","687187"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-12-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD180 molecule, a homologue of TLR-4, expresses on mature B cells.\nA large number of B cells in peripheral blood express CD180 on surface. It\nwas reported that CD180-negative B cells increase in peripheral blood from\npatients with autoimmune diseases such as SLE, a number of CD180-negative\ncells is reflected a stage of the disease, and CD180-negative cells from SLE\npatients produce autoantibodies.  These results suggest that the CD180\nexpression on B cells was strongly concerned with autoimmune reaction. We\npreviously showed that CD180-negative spleen B cells were more\nradiosensitive than CD180-positive cells with regard to apoptosis. In this\nstudy, we attempted to demonstrate the relationship between CD180 expression\nand autoimmune reaction in an animal SLE model, the NZBWF1 mice. Animals\nattained the criteria of disease occurrence were paired according to body\nweight and other conditions.  One of the pair was irradiated with 4 Gy of\nX-rays, and the other sham-irradiated.  After irradiation, the life span of\nthe irradiated mice was significantly increased than that of the\nsham-irradiated mice and same as paired mice. The amount of complement C3 in\nperipheral blood, which decreases as the disease, of the irradiated mice was\nmarkedly higher than their sham-irradiated mice at 3 weeks after\nirradiation. By immunohistological examination of kidneys, number of\nCD180-negative cells of SLE mice increased compared with that before\ndisease.  The findings support the conception that radiation could\neffectively eliminate CD180-negative B cells, leading to the reduced\nproduction of autoantibodies, and thus relieve SLE symptoms. The findings\nsuggest the possibility of practical application of radiotherapy to\nautoimmune diseases.\nCD180 molecule, a homologue of TLR-4, expresses on mature B cells.\nA large number of B cells in peripheral blood express CD180 on surface. It\nwas reported that CD180-negative B cells increase in peripheral blood from\npatients with autoimmune diseases such as SLE, a number of CD180-negative\ncells is reflected a stage of the disease, and CD180-negative cells from SLE\npatients produce autoantibodies.  These results suggest that the CD180\nexpression on B cells was strongly concerned with autoimmune reaction. We\npreviously showed that CD180-negative spleen B cells were more\nradiosensitive than CD180-positive cells with regard to apoptosis. In this\nstudy, we attempted to demonstrate the relationship between CD180 expression\nand autoimmune reaction in an animal SLE model, the NZBWF1 mice. Animals\nattained the criteria of disease occurrence were paired according to body\nweight and other conditions.  One of the pair was irradiated with 4 Gy of\nX-rays, and the other sham-irradiated.  After irradiation, the life span of\nthe irradiated mice was significantly increased than that of the\nsham-irradiated mice and same as paired mice. The amount of complement C3 in\nperipheral blood, which decreases as the disease, of the irradiated mice was\nmarkedly higher than their sham-irradiated mice at 3 weeks after\nirradiation. By immunohistological examination of kidneys, number of\nCD180-negative cells of SLE mice increased compared with that before\ndisease.  The findings support the conception that radiation could\neffectively eliminate CD180-negative B cells, leading to the reduced\nproduction of autoantibodies, and thus relieve SLE symptoms. The findings\nsuggest the possibility of practical application of radiotherapy to\nautoimmune diseases.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第39回日本免疫学会総会・学術集会、","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"687180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"687181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuwabara, Taku"}],"nameIdentifiers":[{"nameIdentifier":"687182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"687183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamata, Itaru"}],"nameIdentifiers":[{"nameIdentifier":"687184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akasaka, Yoshikiyo"}],"nameIdentifiers":[{"nameIdentifier":"687185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Hisaharu"}],"nameIdentifiers":[{"nameIdentifier":"687186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"桑原 卓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"687190","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Induced Life Extension in SLE-Model Mice by Irradiation that Selectively Eliminated CD180-Negative B Cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Induced Life Extension in SLE-Model Mice by Irradiation that Selectively Eliminated CD180-Negative B Cells."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-07"},"publish_date":"2009-12-07","publish_status":"0","recid":"69986","relation_version_is_last":true,"title":["Induced Life Extension in SLE-Model Mice by Irradiation that Selectively Eliminated CD180-Negative B Cells."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:08:08.179326+00:00"}