@misc{oai:repo.qst.go.jp:00069974, author = {Matsumoto, Kenichiro and Nyuui, Minako and Kamibayashi, Masato and Ozawa, Toshihiko and Nakanishi, Ikuo and Anzai, Kazunori and 松本 謙一郎 and 乳井 美奈子 and 上林 將人 and 小澤 俊彦 and 中西 郁夫 and 安西 和紀}, month = {Nov}, note = {Interest for hyperthermia clinical cancer treatment has been increased recently, especially in combination use with existing treatments, i.e. chemotherapy, radiotherapy and immunotherapy to increase efficiency of those treatments. Mechanism for hyperthermal cell killing or sensitization to other stresses/treatments has been unclear. Relation of reactive oxygen species (ROS) to the effect of hyperthermia has been widely alleged and/or reported. Nitroxyl radicals have been conventionally used as chemical redox probe in vitro and in vivo experiments in fields of electron paramagnetic resonance (EPR) spectroscopy. GSH-depending EPR signal loss of nitroxyl radicals was occurred temperature dependently. Details of temperature depending reaction of nitroxyl radicals and GSH were investigated. Some results in this study gave a suspicion of a temperature dependent induction of oxygen depending ROS formation in an aqueous solution. Possible mechanisms of the temperature depending free radical reactions in water was discussed., SFRBM's 16th Annual Meeting}, title = {Temperature depending free radical reaction in water}, year = {2009} }