{"created":"2023-05-15T14:51:10.636198+00:00","id":69960,"links":{},"metadata":{"_buckets":{"deposit":"2c2210be-75ca-479c-9977-88190d9cb092"},"_deposit":{"created_by":1,"id":"69960","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69960"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069960","sets":["10:28"]},"author_link":["686940","686942","686936","686939","686941","686943","686938","686937"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は、リンＫ殻共鳴内殻電離を生じるエネルギーのX線では通常のX線に比べて致死効果が高いこと、およびほ乳類細胞に生じる染色体切断が、細胞内で修復されにくいことを示すデータを得たことを受け、DNA二重鎖切断修復欠損細胞を用いて致死効果を調べたところ、相同組み換え修復欠損、非相同末端結合修復欠損ともに野生株とほとんど差のない反応を示す結果を得て、第45回影響学会で報告した。内殻電離により修復されにくいDNA損傷ができるのであれば、もともと修復に欠損のある細胞では通常のX線の場合との致死効果の違いは正常細胞より小さくなるはずであり、実際に中性子線や重粒子線では差が小さくなると報告されている。そこで今年度はこのリンＫ殻内殻電離により生じるDNA2重鎖切断生成と修復を調べる目的でgamma-X2AXの量を測定した。\nKEK物構研・放射光BL27AポートにおいてリンＫ殻共鳴エネルギー(2.153KeV)およびその低エネルギー側(2.146keV)をL5178Y細胞に照射し、20分間37度Ｃで培養した後のgamma-H2AX量をフローサイトメトリーにて測定した。リンＫ殻共鳴エネルギー(2.153keV)を照射した場合は低エネルギー側(2.146keV)の約1.5倍のgamma-H2AXが存在した。これは致死効果における場合とほぼ同等の割合であった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第52回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"江口−笠井, 清美"}],"nameIdentifiers":[{"nameIdentifier":"686936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇佐美, 徳子"}],"nameIdentifiers":[{"nameIdentifier":"686937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前澤, 博"}],"nameIdentifiers":[{"nameIdentifier":"686938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 克己"}],"nameIdentifiers":[{"nameIdentifier":"686939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井 清美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇佐美 徳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前澤 博","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林 克己","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686943","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"リンK殻内殻電離によるDNA損傷の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リンK殻内殻電離によるDNA損傷の解析"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-11-17"},"publish_date":"2009-11-17","publish_status":"0","recid":"69960","relation_version_is_last":true,"title":["リンK殻内殻電離によるDNA損傷の解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:08:26.084718+00:00"}