@misc{oai:repo.qst.go.jp:00069934,
 author = {Sugahara, Shinji and Kamada, Tadashi and Imai, Reiko and Tsuji, Hiroshi and Suzuki, Motohisa and Okada, Tohru and Tsujii, Hirohiko and Tatezaki, Shinichiroh and 菅原 信二 and 鎌田 正 and 今井 礼子 and 辻 比呂志 and 鈴木 志恒 and 岡田 徹 and 辻井 博彦 and 舘崎 愼一郎},
 month = {Nov},
 note = {OBJECTIVE: To determine the effectiveness of carbon ion radiotherapy (CIRT) for localized primary sarcoma of the extremities.
PATIENTS AND METHODS: From April 2000 to February 2009, 16 (male/female:11/5) patients with localized primary sarcoma of the extremities received CIRT. Age ranged from 14 to 83 years (median 53 years). Nine patients had primary diseases and 7 had recurrent diseases. Of 16 patients, 8 refused amputation, remaining 8 refused surgical resection. Tumors located upper limbs in 4 patients and lower limbs in 12. Histological diagnoses were as follows: malignant fibrous histiocytoma in 4, osteoarcoma in 3, malignant peripheral nerve sheath tumor in 2, synovial sarcoma in 2, and miscellaneous in 5 patients. The CIRT dose to the limb was 52.8 GyE for 1 patient, 64GyE for 4, 70.4GyE for 11 in fixed16 fractions over 4weeks. Records were reviewed and outcomes including radiologic response, local control (progression-free), and survival were analyzed.
RESULTS: The median follow-up was 25 months (range: 5 to 70 months). Radiological response rate was 56% (PR in 9, SD in 6, PD in 1). The local control rates at 4 years were 75%. The overall survival rates at 4 years were 69%. 12 Of 16 patients were alive without disease progression, 3 patients were died due to systemic disease and remaining one was died due to leukemia 57 months after CIRT. No toxicity greater than Grade 2 was observed.
CONCLUSION: CIRT is suggested to be an effective and safe treatment for patients who refused surgery with localized primary sarcoma of the extremities., 15th Annual CTOS Meeting},
 title = {Carbon ion radiotherapy for localized primary sarcoma of the extremities},
 year = {2009}
}