{"created":"2023-05-15T14:51:08.770254+00:00","id":69917,"links":{},"metadata":{"_buckets":{"deposit":"64c38473-b7c0-4b36-85d1-321270e0102f"},"_deposit":{"created_by":1,"id":"69917","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69917"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069917","sets":["10:28"]},"author_link":["686524","686525"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Pregnancy-induced hypertention (PIH), major cause of maternal morbidity and mortality, is considered to be a multifactorial disease resulting from an interaction among several factors including endothelial injury.  Tumor necrosis factor-alpha (TNF-A) fundamentally effects on the endothelial cells by several pathways, such as oxidant/anti-oxidant balances, changing patterns of prostaglandin production and expression of cell surface components.  Some recent studies have reported that an association between a common variants in promoter region (G-308A) of the TNF-A gene and PIH in some racial population, however, it has been yet confirmed.  In the present study, we genotyped and analyzed the variant and other genetic and environment risk factors in order to confirm the association in the Japanese subjects.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"THe 59th Annual Meeting of The American Society of Human Genetics","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobashi, Gen"}],"nameIdentifiers":[{"nameIdentifier":"686524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小橋 元","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"686525","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A common variant of tumor necrosis factor-alpha gene and pregnancy-induced hypertention in Japan","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A common variant of tumor necrosis factor-alpha gene and pregnancy-induced hypertention in Japan"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-26"},"publish_date":"2009-10-26","publish_status":"0","recid":"69917","relation_version_is_last":true,"title":["A common variant of tumor necrosis factor-alpha gene and pregnancy-induced hypertention in Japan"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:08:56.462935+00:00"}