@misc{oai:repo.qst.go.jp:00069904,
 author = {Ohashi, Seiya and Yoshikawa, Kyosan and Toubaru, Sachiko and Hasebe, Mitsuhiko and Ishikawa, Hiroyuki and Sagou, Kenji and Tamura, Katsumi and Tanimoto, Katsuyuki and Kandatsu, Susumu and Mizoe, Junetsu and Fukumura, Toshimitsu and Saga, Tsuneo and Kawaguchi, Koji and Tsujii, Hirohiko and 大橋 靖也 and 吉川 京燦 and 桃原 幸子 and 長谷部 充彦 and 石川 博之 and 田村 克巳 and 谷本 克之 and 神立 進 and 溝江 純悦 and 福村 利光 and 佐賀 恒夫 and 辻井 博彦},
 month = {Oct},
 note = {PURPOSE We sometimes encounter nodular activities in neck area on whole body PET/CT using C-11 methionine (MET) of patients with cancer. We evaluated detectability of MET-PET/CT for neck lymphnode metastasis from head and neck tumor or from the other primary origin tumor of trunk. METHODS AND MATERIALS We reviewed MET-PET/CT images of 1749 studies, from June 2006 to February 2007, searching for any nodular accumulation in neck area. We picked up 84 patients with any nodular accumulation in neck area as suspicious candidates for lymphnode metastasis. There were 91 lesions in total, and 47 nodules were from head and neck cancer and 44 nodules were from other primary origin tumor of trunk. All sites of nodular accumulation were confirmed by pathology or by clinical follow-up. We evaluated diagnostic indexes and made ROC curve analysis. We use TNR, tumor to normal tissue ratio, to estimate MET accumulation. We analyzed the relationship between TNR and the final diagnostic result of the neck region. RESULTS Twenty-eight nodules in 26 patients found out as metastasis. Twenty-five positive nodules were from head and neck cancers and only 3 positive nodules were from other primary origin tumor of trunk. Each positive ratio was 53.2% and 6.8%. When we use 2.48 TNR as cutoff value to diagnose metastasis from 91 nodules, sensitivity, specificity and accuracy were 53.6%, 85.7% and 75.8%, respectively. When we use the same cutoff value for cases with head and neck cancer, sensitivity and specificity and accuracy were 56.0%, 81.8% and 68.9%, and for cases with other primary origin tumor of trunk, they were 66.7%,87.8% and 86.4%, respectively. We had very few neck lymphnode metastasis from trunk cancers, but the diagnostic capabilities (especially specificity and accuracy) of neck lymphnode from trunk cancers were very high. From ROC curve analysis, Az value was 74.4 for all 91 nodules. CONCLUSION MET-PET/CT was useful for diagnosis of neck lymphnode metastasis and especially specificity was relatively high. There were very few true positive metastasis in neck lymphnode accumulation in MET-PET/CT study from trunk cancers compared to head and neck cancers. But diagnostic capability for neck lymphnode metastasis from trunk cancers was higher than from head and neck cancers., The 2009 EANM Congress},
 title = {Diagnostic capability of C-11 methionine PET/CT for neck lymphnode metastasis from head and neck cancers versus trunk cancers},
 year = {2009}
}