@misc{oai:repo.qst.go.jp:00069890,
 author = {Takahashi, Erika and Kakinuma, Shizuko and Amasaki, Yoshiko and Takabatake, Takashi and Nishimura, Mayumi and Kubo, Ayumi and Imaoka, Tatsuhiko and Nogawa, Hiroyuki and Shimada, Yoshiya and 高橋 江里佳 and 柿沼 志津子 and 甘崎 佳子 and 高畠 貴志 and 西村 まゆみ and 久保 歩 and 今岡 達彦 and 島田 義也},
 month = {Oct},
 note = {One of the important concerns for astronauts in space environment is cancer risk associated with cosmic radiation, including heavy particle carbon ions. But little information on cancer risk is available. Biological effects of heavy ions have been extensively investigated using HIMAC and GSI synchrotrons, and generally high RBEs for cell killing and mutation induction have been shown. Murine T-cell lymphomas (TL) can be reproducibly induced by carcinogenic agents such as radiation and chemicals, and this murine model is considered to be useful in the search for characterization of genes involved in the development of human lymphocytic leukemia. In our previous studies, B6C3F1 female mice were exposed to 1.6 Gy whole-body carbon-ion radiation (290 MeV/u; dose average LET, 60 keV/um, spread-out Bragg peak, 6 cm) for 4 consecutive weeks or to 1.6 Gy X-ray radiation. Carbon-induced and X-ray-induced lymphomas showed similar phenotypes, except size of lymphomas. Molecular analysis revealed that the high frequency of loss of heterozygosity (LOH) on chromosomes 4, 11, 12 and 19 in both lymphomas.There was a clear difference of LOH status between two lymphomas; its frequency was much higher for chromosome 11 but lower for chromosome 12 in carbon-ion-induced lymphomas compared to X-ray-induced ones, suggesting mechanistic difference between carbon-ion- and X-ray-induced lymphomagenesis. In the present study, we aimed to clarify the carbon-ion-specific genomic changes. The region of frequent LOH on chromosome 11 was determined using 11 microsatellite markers, and the difference was not found. The alterations of Ikaros on chromosome 11, including altered splicing, point mutations, null expression and insertion, were analyzed. The alteration of Ikaros was similar between the carbon-ion- and X-ray-induced lymphomas., 第23回日本宇宙生物科学会},
 title = {Genetic changes in heavy-ion-induced T-cell lymphomas in B6C3F1 mice},
 year = {2009}
}