{"created":"2023-05-15T14:51:06.273403+00:00","id":69860,"links":{},"metadata":{"_buckets":{"deposit":"17292457-2929-48c5-8555-23cbefc7bca1"},"_deposit":{"created_by":1,"id":"69860","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69860"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069860","sets":["10:28"]},"author_link":["685858","685860","685856","685863","685861","685859","685862","685855","685864","685857"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-09-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"メダカでは古くから発ガン研究がおこなわれており、これまでに多くの研究データが蓄積している。放医研では江藤久美らにより、これまでに2種類のガン培養株が樹立され、保存されている。その中の一つOLME-104はメダカ近交系HB32C由来のメラノーマ（黒色腫）であり、これまでに拒絶反応なしに同近交系種間で移植が可能である事が示されていた。今回、OLME-104にactin-GFPベクターを取り込ませ、恒常的にGFPを発現するメラノーマ培養細胞を作製し、近縁の近交系HB32Dに移植した。すると拒絶反応なしに増殖、転移し、メラノーマ細胞の局在をシングルセルレベルの解像度でリアルタイムに追っていく事が可能になった。また、移植前の宿主に放射線（Ｘ線　〜10Gy）を照射することで、ガン転移の頻度が上昇する事も示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第15回小型魚類研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丸山, 耕一"}],"nameIdentifiers":[{"nameIdentifier":"685855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹中, 光"}],"nameIdentifiers":[{"nameIdentifier":"685856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"685857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"685858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川, 純崇"}],"nameIdentifiers":[{"nameIdentifier":"685859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山 耕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹中 光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 純崇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685864","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"メダカ担ガンモデルの構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"メダカ担ガンモデルの構築"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-29"},"publish_date":"2009-09-29","publish_status":"0","recid":"69860","relation_version_is_last":true,"title":["メダカ担ガンモデルの構築"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:09:35.855535+00:00"}